Phenotyping of subjects for large scale studies on patients with IBS

被引：47

作者：

Boeckxstaens, G. E. ^{[1
,2
]}

Drug, V. ^{[3
]}

Dumitrascu, D. ^{[4
]}

Farmer, A. D. ^{[5
,6
]}

Hammer, J. ^{[7
]}

Hausken, T. ^{[8
]}

Niesler, B. ^{[9
]}

Pohl, D. ^{[10
]}

Pojskic, L. ^{[11
]}

Polster, A. ^{[12
]}

Simren, M. ^{[12
,13
]}

Goebel-Stengel, M. ^{[14
]}

Van Oudenhove, L. ^{[1
,2
]}

Vassallo, M. ^{[15
]}

Wensaas, K. -A. ^{[16
]}

Aziz, Q. ^{[5
]}

Houghton, L. A. ^{[17
,18
,19
,20
]}

机构：

[1] KULeuven, Translat Res Ctr Gastrointestinal Disorders, Leuven, Belgium

[2] Univ Hosp Leuven, Dept Gastroenterol & Hepatol, Leuven, Belgium

[3] Gr T Popa Univ Med & Pharm, Univ Hosp St Spiridon, Dept Gastroenterol, Iasi, Romania

[4] Iuliu Hatieganu Univ Med & Pharm, Dept Med 2, Cluj Napoca, Romania

[5] Barts & London Queen Marys Sch Med & Dent, Wingate Inst Neurogastroenterol, London, England

[6] Univ Hosp North Midlands, Dept Gastroenterol, Stoke On Trent, Staffs, England

[7] Med Univ Wien, Univ Klin Innere Med 3, Vienna, Austria

[8] Haukeland Hosp, Gastroenterol Unit, Dept Med, Bergen, Norway

[9] Heidelberg Univ, Dept Human Mol Genet, Heidelberg, Germany

[10] Univ Zurich Hosp, Div Gastroenterol & Hepatol, Zurich, Switzerland

[11] Univ Sarajevo, Inst Genet Engn & Biotechnol, Sarajevo, Bosnia & Herceg

[12] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Internal Med & Clin Nutr, Gothenburg, Sweden

[13] Univ North Carolina Chapel Hill, Ctr Funct Gastrointestinal & Motil Disorders, Chapel Hill, NC USA

[14] Martin Luther Krankenhaus, Dept Internal Med, Berlin, Germany

[15] Mater Dei Hosp, Dept Med, Tal Qroqq, Malta

[16] Uni Res Hlth, Res Unit Gen Practice, Bergen, Norway

[17] Univ Leeds, Leeds Inst Biomed & Clin Sci, Leeds, W Yorkshire, England

[18] Leeds Teaching Hosp Trust, Leeds Gastroenterol Inst, Leeds, W Yorkshire, England

[19] Univ Manchester, Ctr Gastrointestinal Sci, Manchester, Lancs, England

[20] Mayo Clin, Div Gastroenterol & Hepatol, Jacksonville, FL 32224 USA

来源：

NEUROGASTROENTEROLOGY AND MOTILITY | 2016年 / 28卷 / 08期

关键词：

functional gastrointestinal disorders; irritable bowel syndrome; phenotyping; IRRITABLE-BOWEL-SYNDROME; QUALITY-OF-LIFE; FUNCTIONAL GASTROINTESTINAL DISORDERS; STOOL FORM SCALE; NEPEAN DYSPEPSIA; VISCERAL HYPERSENSITIVITY; RECTAL DISTENSION; GUT TRANSIT; SYMPTOMS; SEVERITY;

D O I：

10.1111/nmo.12886

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Irritable bowel syndrome (IBS) is a complex condition with multiple factors contributing to its aetiology and pathophysiology. Aetiologically these include genetics, life-time events and environment, and physiologically, changes in motility, central processing, visceral sensitivity, immunity, epithelial permeability and gastrointestinal microflora. Such complexity means there is currently no specific reliable biomarker for IBS, and thus IBS continues to be diagnosed and classified according to symptom based criteria, the Rome Criteria. Carefully phenotyping and characterisation of a 'large' pool of IBS patients across Europe and even the world however, might help identify sub-populations with accuracy and consistency. This will not only aid future research but improve tailoring of treatment and health care of IBS patients. Purpose The aim of this position paper is to discuss the requirements necessary to standardize the process of selecting and phenotyping IBS patients and how to organise the collection and storage of patient information/samples in such a large multi-centre pan European/global study. We include information on general demographics, gastrointestinal symptom assessment, psychological factors, quality of life, physiological evaluation, genetic/epigenetic and microbiota analysis, biopsy/blood sampling, together with discussion on the organisational, ethical and language issues associated with implementing such a study. The proposed approach and documents selected to be used in such a study was the result of a thoughtful and thorough four-year dialogue amongst experts associated with the European COST action BM1106 GENIEUR (www.GENIEUR.eu).

引用

页码：1134 / 1147

页数：14

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