Stereoselective synthesis of a candoxatril intermediate via asymmetric hydrogenation

被引：13

作者：

Challenger, S ^{[1
]}

Derrick, A ^{[1
]}

Mason, CP ^{[1
]}

Silk, TV ^{[1
]}

机构：

[1] Pfizer Ltd, Cent Res, Dept Proc Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(98)02687-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A four step synthesis of a chiral glutarate half ester intermediate, required for the preparation of candoxatril, has been developed from t-butyl acrylate. The key steps in this route include a stereoselective synthesis of a trisubstituted alkene and its asymmetric hydrogenation with a Ru-BINAP catalyst. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2187 / 2190

页数：4

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