Possible mechanisms underlying the cholesterol-raising effect of the coffee diterpene cafestol

被引：27
作者：
de Roos, B
Katan, MB
机构：
[1] Wageningen Ctr Food Sci, Div Human Nutr & Epidemiol, Wageningen, Netherlands
[2] Wageningen Univ Agr, Wageningen, Netherlands
来源：
CURRENT OPINION IN LIPIDOLOGY | 1999年 / 10卷 / 01期
关键词：
D O I：
10.1097/00041433-199902000-00008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cafestol, a coffee diterpene present in unfiltered coffee brews, potently raises serum lipids in humans. The mechanism through which this dietary compound influences lipoprotein metabolism is largely unknown. Unravelling the mechanism of action might lead to new insights into the regulation of serum cholesterol levels in humans. This review summaries ways in which cafestol may act on serum lipids. Curr Opin Lipidol 10:41-45. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码：41 / 45
页数：5
相关论文
共 21 条
[1]   DOSE-DEPENDENT EFFECT ON SERUM-CHOLESTEROL AND APOPROTEIN-B CONCENTRATIONS BY CONSUMPTION OF BOILED, NONFILTERED COFFEE [J].
ARO, A ;
TEIRILA, J ;
GREF, CG .
ATHEROSCLEROSIS, 1990, 83 (2-3) :257-261
[2]   The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor [J].
Brown, MS ;
Goldstein, JL .
CELL, 1997, 89 (03) :331-340
[3]   Levels of cafestol, kahweol, and related diterpenoids in wild species of the coffee plant Coffea [J].
deRoos, B ;
vanderWeg, G ;
Urgert, R ;
vandeBovenkamp, P ;
Charrier, A ;
Katan, MB .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1997, 45 (08) :3065-3069
[4]   LOW-DENSITY LIPOPROTEIN PATHWAY AND ITS RELATION TO ATHEROSCLEROSIS [J].
GOLDSTEIN, JL ;
BROWN, MS .
ANNUAL REVIEW OF BIOCHEMISTRY, 1977, 46 :897-930
[5]   Analysis of the content of the diterpenes cafestol and kahweol in coffee brews [J].
Gross, G ;
Jaccaud, E ;
Huggett, AC .
FOOD AND CHEMICAL TOXICOLOGY, 1997, 35 (06) :547-554
[6]  
Halvorsen B, 1998, J LIPID RES, V39, P901
[7]   END OF THE COFFEE MYSTERY - DITERPENE ALCOHOLS RAISE SERUM LOW-DENSITY-LIPOPROTEIN CHOLESTEROL AND TRIGLYCERIDE LEVELS [J].
HECKERS, H ;
GOBEL, U ;
KLEPPEL, U .
JOURNAL OF INTERNAL MEDICINE, 1994, 235 (02) :192-193
[8]   CONSUMPTION OF BOILED COFFEE IS CORRELATED WITH SERUM-CHOLESTEROL IN FINLAND [J].
PIETINEN, P ;
ARO, A ;
TUOMILEHTO, J ;
UUSITALO, U ;
KORHONEN, H .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1990, 19 (03) :586-590
[9]   Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes [J].
Post, SM ;
deWit, ECM ;
Princen, HMG .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (11) :3064-3070
[10]  
RANHEIM T, 1995, J LIPID RES, V36, P2079
123