Elevated progesterone during ovarian stimulation for IVF

被引：111

作者：

Al-Azemi, M. ^{[2
]}

Kyrou, D. ^{[1
]}

Kolibianakis, E. M. ^{[1
]}

Humaidan, P. ^{[3
]}

Van Vaerenbergh, I. ^{[4
]}

Devroey, P. ^{[4
]}

Fatemi, H. M. ^{[4
]}

机构：

[1] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Human Reprod Unit, Sch Med,Dept Obstet & Gynaecol, Thessaloniki 54603, Greece

[2] Kuwait Univ, Fac Med, Dept Obstet & Gynaecol, Safat 13110, Kuwait

[3] Odense Univ Hosp, Fertil Clin, DK-5000 Odense C, Denmark

[4] Dutch Speaking Brussels Free Univ, Acad Hosp, Dept Reprod Med, Brussels, Belgium

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2012年 / 24卷 / 04期

关键词：

IVF; ovarian stimulation; progesterone rise; origin; prevention; pregnancy; IN-VITRO FERTILIZATION; HUMAN CHORIONIC-GONADOTROPIN; INTRACYTOPLASMIC SPERM INJECTION; HUMAN MENOPAUSAL GONADOTROPINS; ASSISTED REPRODUCTION CYCLES; FOLLICULAR PHASE; PREMATURE LUTEINIZATION; SERUM PROGESTERONE; EMBRYO-TRANSFER; INVITRO FERTILIZATION;

D O I：

10.1016/j.rbmo.2012.01.010

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

There is an ongoing debate regarding the impact of premature progesterone rise on the IVF outcome. The objective of this review is to assess evidence of poorer ongoing pregnancy rate in IVF cycles with elevated serum progesterone at the end of follicular phase in ovarian stimulation. It also explores the origin of the progesterone rise, potential modifying factors and possible methods to prevent its rise during ovarian stimulation. This review draws on information already published from monitoring progesterone concentrations at the end of follicular phase in ovarian stimulation. The databases of Medline and PubMed were searched to identify relevant publications. Good-quality evidence supports the negative impact on endometrial receptivity of elevated progesterone concentrations at the end of the follicular phase in ovarian stimulation. Future trials should document the cause and origin of premature progesterone in stimulated IVF cycles. (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

引用

页码：381 / 388

页数：8

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