共 43 条
An essential role for the IL-2 receptor in Treg cell function
被引:668
作者:

Chinen, Takatoshi
论文数: 0 引用数: 0
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机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Immunol Program, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

Kannan, Arun K.
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen, Immunol Discovery, Cambridge, MA USA
AbbVie, Biotechnol, N Chicago, IL 60064 USA Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

Levine, Andrew G.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Immunol Program, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

Fan, Xiying
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Immunol Program, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

Klein, Ulf
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY USA
Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA
Columbia Univ, Dept Microbiol & Immunol, New York, NY USA Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

Zheng, Ye
论文数: 0 引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Nomis Fdn, Labs Immunobiol & Microbial Pathogenesis, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

Gasteiger, Georg
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Immunol Program, 1275 York Ave, New York, NY 10021 USA
Johannes Gutenberg Univ Mainz, Med Ctr, Inst Med Microbiol & Hyg, Mainz, Germany Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

Feng, Yongqiang
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Immunol Program, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

Fontenot, Jason D.
论文数: 0 引用数: 0
h-index: 0
机构:
Biogen, Immunol Discovery, Cambridge, MA USA
Juno Therapeut, Exploratory Biol, Seattle, WA 98109 USA Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

Rudensky, Alexander Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Immunol Program, 1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
机构:
[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Immunol Program, 1275 York Ave, New York, NY 10021 USA
[3] Biogen, Immunol Discovery, Cambridge, MA USA
[4] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY USA
[5] Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA
[6] Columbia Univ, Dept Microbiol & Immunol, New York, NY USA
[7] Salk Inst Biol Studies, Nomis Fdn, Labs Immunobiol & Microbial Pathogenesis, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
[8] Johannes Gutenberg Univ Mainz, Med Ctr, Inst Med Microbiol & Hyg, Mainz, Germany
[9] AbbVie, Biotechnol, N Chicago, IL 60064 USA
[10] Juno Therapeut, Exploratory Biol, Seattle, WA 98109 USA
基金:
日本学术振兴会;
美国国家卫生研究院;
关键词:
TRANSCRIPTION FACTOR FOXP3;
IN-VIVO;
SUPPRESSOR FUNCTION;
CUTTING EDGE;
INTERLEUKIN-2;
EXPRESSION;
INDUCTION;
LINEAGE;
STAT5;
GENE;
D O I:
10.1038/ni.3540
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Regulatory T cells (T-reg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by T-reg cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the T-reg cell lineage-specification factor Foxp3, which has confounded experimental efforts to understand the role of IL-2R expression and signaling in the suppressor function of T-reg cells. Using genetic gain-and loss-of-function approaches, we found that capture of IL-2 was dispensable for the control of CD4(+) T cells but was important for limiting the activation of CD8(+) T cells, and that IL-2R-dependent activation of the transcription factor STAT5 had an essential role in the suppressor function of T-reg cells separable from signaling via the T cell antigen receptor.
引用
收藏
页码:1322 / 1333
页数:12
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