mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

被引：6

作者：

Garcia-Beltran, Wilfredo F. ^{[1
,2
]}

St Denis, Kerri J. ^{[2
]}

Hoelzemer, Angelique ^{[3
,4
,5
]}

Lam, Evan C. ^{[2
]}

Nitido, Adam D. ^{[2
,6
]}

Sheehan, Maegan L. ^{[2
]}

Berrios, Cristhian ^{[1
]}

Ofoman, Onosereme ^{[1
]}

Chang, Christina C. ^{[7
,8
]}

Hauser, Blake M. ^{[2
]}

Feldman, Jared ^{[2
,6
]}

Roederer, Alex L. ^{[2
,6
]}

Gregory, David J. ^{[9
,10
]}

Poznansky, Mark C. ^{[9
,11
]}

Schmidt, Aaron G. ^{[2
]}

Iafrate, A. John ^{[1
]}

Naranbhai, Vivek ^{[8
,11
,12
]}

Balazs, Alejandro B. ^{[2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[2] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

[3] Univ Med Ctr Eppendorf, Dept Internal Med 1, Div Infect Dis, Hamburg, Germany

[4] German Ctr Infect Res DZIF, Site Hamburg Lubeck Borstel Riems, Braunschweig, Germany

[5] Leibniz Inst Expt Virol, Res Dept Virus Immunol, Hamburg, Germany

[6] Harvard Med Sch, Div Med Sci, PhD Program Virol, Boston, MA 02115 USA

[7] Monash Univ, Alfred Hosp, Cent Clin Sch, Prahran, Vic 3181, Australia

[8] Ctr AIDS Programme Res South Africa, ZA-4001 Durban, South Africa

[9] Massachusetts Gen Hosp, Vaccine & Immunotherapy Ctr, Boston, MA 02129 USA

[10] Massachusetts Gen Hosp Children, Pediat Infect Dis, Boston, MA 02114 USA

[11] Massachusetts Gen Hosp Canc Ctr, Boston, MA 02114 USA

[12] Dana Farber Canc Inst, Boston, MA 02215 USA

来源：

CELL | 2022年 / 185卷 / 03期

关键词：

ANTIBODY;

D O I：

10.1016/j.cell.2021.12.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we measured the neutralization potency of sera from 88 mRNA-1273, 111 BNT162b, and 40 Ad26.COV2.S vaccine recipients against wild-type, Delta, and Omicron SARS-CoV-2 pseudoviruses. We included individuals that received their primary series recently (<3 months), distantly (6-12 months), or an additional "booster"dose, while accounting for prior SARS-CoV-2 infection. Remarkably, neutralization of Omicron was undetectable in most vaccinees. However, individuals boosted with mRNA vaccines exhibited potent neutralization of Omicron, only 4-6-fold lower than wild type, suggesting enhanced cross-reactivity of neutralizing antibody responses. In addition, we find that Omicron pseudo virus infects more efficiently than other variants tested. Overall, this study highlights the importance of additional mRNA doses to broaden neutralizing antibody responses against highly divergent SARS-CoV-2 variants.

引用

页码：457 / +

页数：15

共 41 条

[41] Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera [J].

Zhou, Daming ;

Dejnirattisai, Wanwisa ;

Supasa, Piyada ;

Liu, Chang ;

Mentzer, Alexander J. ;

Ginn, Helen M. ;

Zhao, Yuguang ;

Duyvesteyn, Helen M. E. ;

Tuekprakhon, Aekkachai ;

Nutalai, Rungtiwa ;

Wang, Beibei ;

Paesen, Guido C. ;

Lopez-Camacho, Cesar ;

Slon-Campos, Jose ;

Hallis, Bassam ;

Coombes, Naomi ;

Bewley, Kevin ;

Charlton, Sue ;

Walter, Thomas S. ;

Skelly, Donal ;

Lumley, Sheila F. ;

Dold, Christina ;

Levin, Robert ;

Dong, Tao ;

Pollard, Andrew J. ;

Knight, Julian C. ;

Crook, Derrick ;

Lambe, Teresa ;

Clutterbuck, Elizabeth ;

Bibi, Sagida ;

Flaxman, Amy ;

Bittaye, Mustapha ;

Belij-Rammerstorfer, Sandra ;

Gilbert, Sarah ;

James, William ;

Carroll, Miles W. ;

Klenerman, Paul ;

Barnes, Eleanor ;

Dunachie, Susanna J. ;

Fry, Elizabeth E. ;

Mongkolsapaya, Juthathip ;

Ren, Jingshan ;

Stuart, David, I ;

Screaton, Gavin R. .

CELL, 2021, 184 (09) :2348-+

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