Cytotoxic Bipyridines from the Marine-Derived Actinomycete Actinoalloteichus cyanogriseus WH1-2216-6

被引：114

作者：

Fu, Peng ^{[1
]}

Wang, Shuxia ^{[1
]}

Hong, Kui ^{[2
]}

Li, Xia ^{[3
]}

Liu, Peipei ^{[1
]}

Wang, Yi ^{[1
]}

Zhu, Weiming ^{[1
]}

机构：

[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China

[2] Wuhan Univ, Coll Pharm, Wuhan 430071, Peoples R China

[3] Shandong Univ Weihai, Marine Coll, Weihai 264209, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 08期

基金：

中国国家自然科学基金;

关键词：

STREPTOMYCES-CAERULEUS BALDACCI; GENUS MARINISPORA; HYDROXAMIC ACIDS; CAERULOMYCIN-A; C-13; NMR; ASSAY; BIOSYNTHESIS; METABOLITES; DISCOVERY;

D O I：

10.1021/np200258h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new bipyridine alkaloids (1-5) and a new phenylpyridine alkaloid (6), which we name caerulomycins F-K, along with five known analogues (7-11), were isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. The structures of 1-6 were established on the basis of spectroscopic analyses and chemical methods. Compounds 1-10 showed cytotoxicity against the HL-60, K562, KB, and A549 cell lines, with IC50 values of 0.26 to 15.7 mu M. Compounds 7 and 8 also showed antimicrobial activities against Escherichia coli, Aerobacter aerogenes, Pseudomonas aeruginosa, and Candida albicans, with MIC values of 9.7 to 38.6 mu M.

引用

页码：1751 / 1756

页数：6

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