Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231)

被引：20

作者：

Aghaei, Mahmoud ^{[1
]}

Yazdiniapour, Zeinab ^{[2
]}

Ghanadian, Mustafa ^{[3
]}

Zolfaghari, Behzad ^{[2
]}

Lanzotti, Virginia ^{[4
]}

Mirsafaee, Vahid ^{[2
]}

机构：

[1] Isfahan Univ Med Sci, Dept Biochem, Esfahan, Iran

[2] Isfahan Univ Med Sci, Dept Pharmacognosy, Esfahan, Iran

[3] Isfahan Univ Med Sci, Isfahan Pharmaceut Sci Res Ctr, Esfahan, Iran

[4] Univ Naples Federico II, Dipartimento Agr, Naples, Italy

来源：

STEROIDS | 2016年 / 115卷

关键词：

Euphorbia sogdiana; 4 alpha-Methyl sterols; Obtusifoliol analogues; Anticancer; Apoptosis; Breast cancer; WHOLE HERB; CHAMAESYCE; DITERPENES; MECHANISM;

D O I：

10.1016/j.steroids.2016.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From the aerial parts of Euphorbia sogdiana Popov, obtusifoliol (1) and two related steroids (2-3) have been isolated and characterized along with a known cycloartane derivative (4). The chemical structure of the obtusifoliol-related compounds, obtained by 1D and 2D NMR, and MS measurements, have been determined as: 3 beta,7 alpha-dihydroxy-4 alpha,14 alpha-dimethyl-5 alpha-ergosta-8,24(28)-diene-11-one (2) and 3 beta-hydroxy-4 alpha,14 alpha-dimethyl-5 alpha-ergosta-8,24(28)-diene-1-one (3). Compound 2 has been previously isolated from Euphorbia chamaesyce while compound 3 was never reported before. The isolated compounds 1-4 were subjected to cytotoxic tests on the breast cancer cells, MCF-7 and MDA-MB231. Further pharmacological tests on the more active compounds 2 and 3 indicated their action to be related to cell growth inhibitory activity and apoptotic effects on the tested cells. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：90 / 97

页数：8

共 17 条

[1] Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance [J].