Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

被引：3
|
作者：
El Fal, Mohammed [1 ]
Ramli, Youssef [2 ]
Zerzouf, Abdelfettah [3 ]
Talbaoui, Ahmed [4 ]
Bakri, Youssef [4 ]
Essassi, El Mokhtar [1 ]
机构：
[1] Univ Mohammed 5, Fac Sci, Lab Chim Organ Heterocycl URAC 21, Rabat, Morocco
[2] Mohammed V Univ, Fac Med & Pharm, Med Chem Lab, Rabat 10170, Morocco
[3] ENS, LPCMIO, Rabat, Morocco
[4] Univ Mohammed 5, Fac Sci, Lab Biochim & Immunol, Rabat, Morocco
来源：
JOURNAL OF CHEMISTRY | 2015年 / 2015卷
关键词：
FACILE SYNTHESIS; CYCLOADDITION; POTENT;
D O I：
10.1155/2015/982404
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data ((HNMR)-H-1, C-13, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains: Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 mu g/mL against Staphylococcus aureus and Streptococcus fasciens.
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页数：6
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