Shedding light on corticosteroid-resistant type 2-high severe asthma

被引:5
作者
Chung, Kian Fan [1 ,2 ]
机构
[1] Imperial Coll London, Natl Heart & Lung Inst, Dovehouse St, London SW3 6LY, England
[2] Royal Brompton & Harefield NHS Trust, London, England
关键词
Asthma; type; 2; inflammation; corticosteroid resistance; eosinophils; INSENSITIVITY; INFLAMMATION;
D O I
10.1016/j.jaci.2018.11.002
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:89 / 90
页数:2
相关论文
共 50 条
  • [41] Exploring the Utility of Noninvasive Type 2 Inflammatory Markers for Prediction of Severe Asthma Exacerbations in Children and Adolescents
    Shah, Samar P.
    Grunwell, Jocelyn
    Shih, Jennifer
    Stephenson, Susan
    Fitzpatrick, Anne M.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2019, 7 (08) : 2624 - +
  • [42] High mobility group box 1: Biomarker of inhaled corticosteroid treatment response in children with moderate-severe asthma
    Manti, Sara
    Leonardi, Salvatore
    Parisi, Giuseppe F.
    De Vivo, Dominique
    Salpietro, Annamaria
    Spinuzza, Antonietta
    Arrigo, Teresa
    Salpietro, Carmelo
    Cuppari, Caterina
    ALLERGY AND ASTHMA PROCEEDINGS, 2017, 38 (03) : 197 - 203
  • [43] Airway hyperresponsiveness to mannitol improves in both type 2 low and type 2 high asthma after specialist management
    Hvidtfeldt, Morten
    Sverrild, Asger
    Backer, Vibeke
    Porsbjerg, Celeste
    EUROPEAN RESPIRATORY JOURNAL, 2019, 54
  • [44] The clinical and pathological histology efficacy of biological therapy for severe asthma with a phenotype of type 2 inflammation - systematic review
    Ma, Junhui
    Ma, Qiang
    Yang, Jing
    Liang, Panpan
    Zhou, Jiaxin
    Ma, Jiarui
    Ma, Fuhua
    Zhuan, Bing
    Zhou, Wei
    FRONTIERS IN IMMUNOLOGY, 2025, 16
  • [45] Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications
    Choi, Youngwoo
    Sim, Soyoon
    Park, Hae-Sim
    KOREAN JOURNAL OF INTERNAL MEDICINE, 2020, 35 (04) : 823 - 833
  • [46] The Prevalence of Subtypes of Type 2 Inflammation in an Unselected Population of Patients with Severe Asthma
    Frossing, Laurits
    Silberbrandt, Alexander
    Von Buelow, Anna
    Backer, Vibeke
    Porsbjerg, Celeste
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2021, 9 (03) : 1267 - 1275
  • [47] The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium
    Bonser, Luke R.
    Eckalbar, Walter L.
    Rodriguez, Lauren
    Shen, Jiangshan
    Koh, Kyung Duk
    Ghias, Khadija
    Zlock, Lorna T.
    Christenson, Stephanie
    Woodruff, Prescott G.
    Finkbeiner, Walter E.
    Erle, David J.
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2022, 66 (04) : 391 - 401
  • [48] Eosinophil extracellular traps activate type 2 innate lymphoid cells through stimulating airway epithelium in severe asthma
    Choi, Youngwoo
    Kim, Young-Min
    Lee, Hee-Ra
    Mun, Jiyeong
    Sim, Soyoon
    Lee, Dong-Hyun
    Pham, Duy Le
    Kim, Seung-Hyun
    Shin, Yoo Seob
    Lee, Seung-Woo
    Park, Hae-Sim
    ALLERGY, 2020, 75 (01) : 95 - 103
  • [49] Dupilumab efficacy in subgroups of type 2 asthma with high-dose inhaled corticosteroids at baseline
    Bourdin, Arnaud
    Virchow, J. Christian
    Papi, Alberto
    Lugogo, Njira L.
    Bardin, Philip
    Antila, Martti
    Halpin, David M. G.
    Daizadeh, Nadia
    Djandji, Michel
    Ortiz, Benjamin
    Jacob-Nara, Juby A.
    Gall, Rebecca
    Deniz, Yamo
    Rowe, Paul J.
    RESPIRATORY MEDICINE, 2022, 202
  • [50] Disconnect of type 2 biomarkers in severe asthma; dominated by FeNO as a predictor of exacerbations and periostin as predictor of reduced lung function
    Mansur, Adel H.
    Srivastava, Sapna
    Sahal, Adeel
    RESPIRATORY MEDICINE, 2018, 143 : 31 - 38