Carbohydrate and Amino Acid Metabolism as Hallmarks for Innate Immune Cell Activation and Function

被引：46

作者：

Zhao, Haoxin ^{[1
]}

Raines, Lydia N. ^{[1
]}

Huang, Stanley Ching-Cheng ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Dept Pathol, Sch Med, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Case Comprehens Canc Ctr, Sch Med, Cleveland, OH 44106 USA

来源：

CELLS | 2020年 / 9卷 / 03期

关键词：

innate immunity; carbohydrates; amino acids; immunometabolism; ENZYMATICALLY SYNTHESIZED GLYCOGEN; MOUSE PERITONEAL-MACROPHAGES; PLASMACYTOID DENDRITIC CELLS; PENTOSE-PHOSPHATE PATHWAY; ARYL-HYDROCARBON RECEPTOR; NITRIC-OXIDE SYNTHASE; SUPPRESSOR-CELLS; L-ARGININE; SUCCINATE-DEHYDROGENASE; ARGININOSUCCINATE SYNTHETASE;

D O I：

10.3390/cells9030562

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immune activation is now understood to be fundamentally linked to intrinsic and/or extrinsic metabolic processes which are essential for immune cells to survive, proliferate, and perform their effector functions. Moreover, disruption or dysregulation of these pathways can result in detrimental outcomes and underly a number of pathologies in both communicable and non-communicable diseases. In this review, we discuss how the metabolism of carbohydrates and amino acids in particular can modulate innate immunity and how perturbations in these pathways can result in failure of these immune cells to properly function or induce unfavorable phenotypes.

引用

页数：22

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