The Necessity of Diploid Genome Sequencing to Unravel the Genetic Component of Complex Phenotypes

被引：5
作者：
Aleman, Fernando [1 ]
机构：
[1] Scripps Res Inst, La Jolla, CA 92037 USA
来源：
FRONTIERS IN GENETICS | 2017年 / 8卷
关键词：
chromosome phasing; diploid alignment; diploid genomes; GWAS (genome-wide association study); structural variants; genetic variants; SNP association study; Diploid Manhattan Plot; GWAS;
D O I：
10.3389/fgene.2017.00148
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
[No abstract available]
引用
收藏
页数：3
相关论文
共 18 条
  • [11] Functional and genomic context in pathway analysis of GWAS data
    Mooney, Michael A.
    Nigg, Joel T.
    McWeeney, Shannon K.
    Wilmot, Beth
    [J]. TRENDS IN GENETICS, 2014, 30 (09) : 390 - 400
  • [12] Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
    Paquet, Dominik
    Kwart, Dylan
    Chen, Antonia
    Sproul, Andrew
    Jacob, Samson
    Teo, Shaun
    Olsen, Kimberly Moore
    Gregg, Andrew
    Noggle, Scott
    Tessier-Lavigne, Marc
    [J]. NATURE, 2016, 533 (7601) : 125 - +
  • [13] Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis
    Safrany, Eniko
    Szabo, Melinda
    Szell, Marta
    Kemeny, Lajos
    Sumegi, Katalin
    Melegh, Bela I.
    Magyari, Lili
    Matyas, Petra
    Figler, Maria
    Weber, Agnes
    Tulassay, Zsolt
    Melegh, Bela
    [J]. INFLAMMATION RESEARCH, 2013, 62 (02) : 195 - 200
  • [14] De novo assembly and phasing of a Korean human genome
    Seo, Jeong-Sun
    Rhie, Arang
    Kim, Junsoo
    Lee, Sangjin
    Sohn, Min-Hwan
    Kim, Chang-Uk
    Hastie, Alex
    Cao, Han
    Yun, Ji-Young
    Kim, Jihye
    Kuk, Junho
    Park, Gun Hwa
    Kim, Juhyeok
    Ryu, Hanna
    Kim, Jongbum
    Roh, Mira
    Baek, Jeonghun
    Hunkapiller, Michael W.
    Korlach, Jonas
    Shin, Jong-Yeon
    Kim, Changhoon
    [J]. NATURE, 2016, 538 (7624) : 243 - +
  • [15] Phasing for medical sequencing using rare variants and large haplotype reference panels
    Sharp, Kevin
    Kretzschmar, Warren
    Delaneau, Olivier
    Marchini, Jonathan
    [J]. BIOINFORMATICS, 2016, 32 (13) : 1974 - 1980
  • [16] A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders
    Subramanian, Lakshmi
    Khan, Abrar A.
    Allu, Prasanna K. R.
    Kiranmayi, Malapaka
    Sahu, Bhavani S.
    Sharma, Saurabh
    Khullar, Madhu
    Mullasari, Ajit S.
    Mahapatra, Nitish R.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (34) : 13970 - 13985
  • [17] An integrated map of structural variation in 2,504 human genomes
    Sudmant, Peter H.
    Rausch, Tobias
    Gardner, Eugene J.
    Handsaker, Robert E.
    Abyzov, Alexej
    Huddleston, John
    Zhang, Yan
    Ye, Kai
    Jun, Goo
    Fritz, Markus Hsi-Yang
    Konkel, Miriam K.
    Malhotra, Ankit
    Stuetz, Adrian M.
    Shi, Xinghua
    Casale, Francesco Paolo
    Chen, Jieming
    Hormozdiari, Fereydoun
    Dayama, Gargi
    Chen, Ken
    Malig, Maika
    Chaisson, Mark J. P.
    Walter, Klaudia
    Meiers, Sascha
    Kashin, Seva
    Garrison, Erik
    Auton, Adam
    Lam, Hugo Y. K.
    Mu, Xinmeng Jasmine
    Alkan, Can
    Antaki, Danny
    Bae, Taejeong
    Cerveira, Eliza
    Chines, Peter
    Chong, Zechen
    Clarke, Laura
    Dal, Elif
    Ding, Li
    Emery, Sarah
    Fan, Xian
    Gujral, Madhusudan
    Kahveci, Fatma
    Kidd, Jeffrey M.
    Kong, Yu
    Lameijer, Eric-Wubbo
    McCarthy, Shane
    Flicek, Paul
    Gibbs, Richard A.
    Marth, Gabor
    Mason, Christopher E.
    Menelaou, Androniki
    [J]. NATURE, 2015, 526 (7571) : 75 - +
  • [18] Direct determination of diploid genome sequences
    Weisenfeld, Neil I.
    Kumar, Vijay
    Shah, Preyas
    Church, Deanna M.
    Jaffe, David B.
    [J]. GENOME RESEARCH, 2017, 27 (05) : 757 - 767
12