The Necessity of Diploid Genome Sequencing to Unravel the Genetic Component of Complex Phenotypes

被引:5
作者
Aleman, Fernando [1 ]
机构
[1] Scripps Res Inst, La Jolla, CA 92037 USA
来源
FRONTIERS IN GENETICS | 2017年 / 8卷
关键词
chromosome phasing; diploid alignment; diploid genomes; GWAS (genome-wide association study); structural variants; genetic variants; SNP association study; Diploid Manhattan Plot; GWAS;
D O I
10.3389/fgene.2017.00148
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页数:3
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共 18 条
  • [1] An Expanded View of Complex Traits: From Polygenic to Omnigenic
    Boyle, Evan A.
    Li, Yang I.
    Pritchard, Jonathan K.
    [J]. CELL, 2017, 169 (07) : 1177 - 1186
  • [2] De novo assembly of a haplotype-resolved human genome
    Cao, Hongzhi
    Wu, Honglong
    Luo, Ruibang
    Huang, Shujia
    Sun, Yuhui
    Tong, Xin
    Xie, Yinlong
    Liu, Binghang
    Yang, Hailong
    Zheng, Hancheng
    Li, Jian
    Li, Bo
    Wang, Yu
    Yang, Fang
    Sun, Peng
    Liu, Siyang
    Gao, Peng
    Huang, Haodong
    Sun, Jing
    Chen, Dan
    He, Guangzhu
    Huang, Weihua
    Huang, Zheng
    Li, Yue
    Tellier, Laurent C. A. M.
    Liu, Xiao
    Feng, Qiang
    Xu, Xun
    Zhang, Xiuqing
    Bolund, Lars
    Krogh, Anders
    Kristiansen, Karsten
    Drmanac, Radoje
    Drmanac, Snezana
    Nielsen, Rasmus
    Li, Songgang
    Wang, Jian
    Yang, Huanming
    Li, Yingrui
    Wong, Gane Ka-Shu
    Wang, Jun
    [J]. NATURE BIOTECHNOLOGY, 2015, 33 (06) : 617 - +
  • [3] Genomic and epigenetic insights into the molecular bases of heterosis
    Chen, Z. Jeffrey
    [J]. NATURE REVIEWS GENETICS, 2013, 14 (07) : 471 - 482
  • [4] A high-quality human reference panel reveals the complexity and distribution of genomic structural variants
    Hehir-Kwa, Jayne Y.
    Marschall, Tobias
    Kloosterman, Wigard P.
    Francioli, Laurent C.
    Baaijens, Jasmijn A.
    Dijkstra, Louis J.
    Abdellaoui, Abdel
    Koval, Vyacheslav
    Thung, Djie Tjwan
    Wardenaar, Rene
    Renkens, Ivo
    Coe, Bradley P.
    Deelen, Patrick
    de Ligt, Joep
    Lameijer, Eric-Wubbo
    van Dijk, Freerk
    Hormozdiari, Fereydoun
    Uitterlinden, Andre G.
    van Duijn, Cornelia M.
    Eichler, Evan E.
    de Bakker, Paul I. W.
    Swertz, Morris A.
    Wijmenga, Cisca
    van Ommen, Gert-Jan B.
    Slagboom, P. Eline
    Boomsma, Dorret I.
    Schonhuth, Alexander
    Ye, Kai
    Guryev, Victor
    [J]. NATURE COMMUNICATIONS, 2016, 7
  • [5] Natural Variations and Genome-Wide Association Studies in Crop Plants
    Huang, Xuehui
    Han, Bin
    [J]. ANNUAL REVIEW OF PLANT BIOLOGY, VOL 65, 2014, 65 : 531 - 551
  • [6] Complement factor H polymorphism in age-related macular degeneration
    Klein, RJ
    Zeiss, C
    Chew, EY
    Tsai, JY
    Sackler, RS
    Haynes, C
    Henning, AK
    SanGiovanni, JP
    Mane, SM
    Mayne, ST
    Bracken, MB
    Ferris, FL
    Ott, J
    Barnstable, C
    Hoh, J
    [J]. SCIENCE, 2005, 308 (5720) : 385 - 389
  • [7] The advantages and limitations of trait analysis with GWAS: a review
    Korte, Arthur
    Farlow, Ashley
    [J]. PLANT METHODS, 2013, 9
  • [8] The diploid genome sequence of an individual human
    Levy, Samuel
    Sutton, Granger
    Ng, Pauline C.
    Feuk, Lars
    Halpern, Aaron L.
    Walenz, Brian P.
    Axelrod, Nelson
    Huang, Jiaqi
    Kirkness, Ewen F.
    Denisov, Gennady
    Lin, Yuan
    MacDonald, Jeffrey R.
    Pang, Andy Wing Chun
    Shago, Mary
    Stockwell, Timothy B.
    Tsiamouri, Alexia
    Bafna, Vineet
    Bansal, Vikas
    Kravitz, Saul A.
    Busam, Dana A.
    Beeson, Karen Y.
    Mclntosh, Tina C.
    Remington, Karin A.
    Abril, Josep F.
    Gill, John
    Borman, Jon
    Rogers, Yu-Hui
    Frazier, Marvin E.
    Scherer, Stephen W.
    Strausberg, Robert L.
    Venter, J. Craig
    [J]. PLOS BIOLOGY, 2007, 5 (10) : 2113 - 2144
  • [9] In Retrospect A decade of shared genomic associations
    Manolio, Teri A.
    [J]. NATURE, 2017, 546 (7658) : 360 - 361
  • [10] How Single Molecule Real-Time Sequencing and Haplotype Phasing Have Enabled Reference-Grade Diploid Genome Assembly of Wine Grapes
    Minio, Andrea
    Lin, Jerry
    Gaut, Brandon S.
    Cantu, Dario
    [J]. FRONTIERS IN PLANT SCIENCE, 2017, 8