The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises

被引：33
作者：
Ortega, Angel [1 ]
Vera, Ivana [1 ]
Diaz, Maria P. [1 ]
Navarro, Carla [1 ]
Rojas, Milagros [1 ]
Torres, Wheeler [1 ]
Parra, Heliana [1 ]
Salazar, Juan [1 ]
De Sanctis, Juan B. [2 ]
Bermudez, Valmore [3 ]
机构：
[1] Univ Zulia, Sch Med, Endocrine & Metab Dis Res Ctr, Maracaibo 4004, Venezuela
[2] Palacky Univ Olomouc, Inst Mol & Translat Med, Fac Med & Dent, Olomouc 77900, Czech Republic
[3] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla 080002, Colombia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 01期
关键词：
YAP; TAZ; TEAD; Hippo signaling pathway; carcinogenesis; tumor microenvironment; neoplastic stem cells; cell proliferation; drug resistance; chemoresistance; immunotherapy; EPITHELIAL-MESENCHYMAL TRANSITION; HIPPO PATHWAY; BREAST-CANCER; CLINICAL-IMPLICATIONS; MEDIATES RESISTANCE; MEVALONATE PATHWAY; TARGETING YAP; ORGAN SIZE; TAZ; PROMOTES;
D O I：
10.3390/ijms23010430
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, embryonic development, regeneration, proliferation, and cancer origin and progression. The mechanism involves the nuclear binding of the un-phosphorylated YAP/TAZ complex to release the transcriptional enhanced associate domain (TEAD) from its repressors. The active ternary complex is responsible for the aforementioned biological effects. Overexpression of YAP/TAZ has been reported in cancer stem cells and tumor resistance. The resistance involves chemotherapy, targeted therapy, and immunotherapy. This review provides an overview of YAP/TAZ pathways' role in carcinogenesis and tumor microenvironment. Potential therapeutic alternatives are also discussed.
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页数：22
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