EZH2: a pleiotropic protein

被引：7
作者：
Burmeister, Thomas [1 ]
机构：
[1] Charite, Berlin, Germany
来源：
BLOOD | 2016年 / 128卷 / 07期
关键词：
MUTATIONS; CANCER;
D O I：
10.1182/blood-2016-06-723916
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Yan et al report their findings in natural killer/T-cell lymphoma (NKTL) and present experimental evidence that EZH2 can act as a transcriptional activator, independent of its methyltransferase activity, when phosphorylated by JAK3. This may open up the prospect of new treatment options for a variety of neoplasms, where EZH2 is known to be involved. © 2016 by The American Society of Hematology.
引用
收藏
页码：888 / 889
页数：4
相关论文
共 10 条
  • [1] Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    Ernst, Thomas
    Chase, Andrew J.
    Score, Joannah
    Hidalgo-Curtis, Claire E.
    Bryant, Catherine
    Jones, Amy V.
    Waghorn, Katherine
    Zoi, Katerina
    Ross, Fiona M.
    Reiter, Andreas
    Hochhaus, Andreas
    Drexler, Hans G.
    Duncombe, Andrew
    Cervantes, Francisco
    Oscier, David
    Boultwood, Jacqueline
    Grand, Francis H.
    Cross, Nicholas C. P.
    [J]. NATURE GENETICS, 2010, 42 (08) : 722 - U109
  • [2] EZH2 in normal hematopoiesis and hematological malignancies
    Herviou, Laurie
    Cavalli, Giacomo
    Cartron, Guillaume
    Klein, Bernard
    Moreaux, Jerome
    [J]. ONCOTARGET, 2016, 7 (03) : 2284 - 2296
  • [3] Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells
    Kim, Eunhee
    Kim, Misuk
    Woo, Dong-Hun
    Shin, Yongjae
    Shin, Jihye
    Chang, Nakho
    Oh, Young Taek
    Kim, Hong
    Rheey, Jingeun
    Nakano, Ichiro
    Lee, Cheolju
    Joo, Kyeung Min
    Rich, Jeremy N.
    Nam, Do-Hyun
    Lee, Jeongwu
    [J]. CANCER CELL, 2013, 23 (06) : 839 - 852
  • [4] Targeting EZH2 in cancer
    Kim, Kimberly H.
    Roberts, Charles W. M.
    [J]. NATURE MEDICINE, 2016, 22 (02) : 128 - 134
  • [5] Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
    McCabe, Michael T.
    Graves, Alan P.
    Ganji, Gopinath
    Diaz, Elsie
    Halsey, Wendy S.
    Jiang, Yong
    Smitheman, Kimberly N.
    Ott, Heidi M.
    Pappalardi, Melissa B.
    Allen, Kimberly E.
    Chen, Stephanie B.
    Della Pietra, Anthony, III
    Dul, Edward
    Hughes, Ashley M.
    Gilbert, Seth A.
    Thrall, Sara H.
    Tummino, Peter J.
    Kruger, Ryan G.
    Brandt, Martin
    Schwartz, Benjamin
    Creasy, Caretha L.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (08) : 2989 - 2994
  • [6] Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
    Morera, Ludovica
    Luebbert, Michael
    Jung, Manfred
    [J]. CLINICAL EPIGENETICS, 2016, 8 : 16
  • [7] Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    Morin, Ryan D.
    Johnson, Nathalie A.
    Severson, Tesa M.
    Mungall, Andrew J.
    An, Jianghong
    Goya, Rodrigo
    Paul, Jessica E.
    Boyle, Merrill
    Woolcock, Bruce W.
    Kuchenbauer, Florian
    Yap, Damian
    Humphries, R. Keith
    Griffith, Obi L.
    Shah, Sohrab
    Zhu, Henry
    Kimbara, Michelle
    Shashkin, Pavel
    Charlot, Jean F.
    Tcherpakov, Marianna
    Corbett, Richard
    Tam, Angela
    Varhol, Richard
    Smailus, Duane
    Moksa, Michelle
    Zhao, Yongjun
    Delaney, Allen
    Qian, Hong
    Birol, Inanc
    Schein, Jacqueline
    Moore, Richard
    Holt, Robert
    Horsman, Doug E.
    Connors, Joseph M.
    Jones, Steven
    Aparicio, Samuel
    Hirst, Martin
    Gascoyne, Randy D.
    Marra, Marco A.
    [J]. NATURE GENETICS, 2010, 42 (02) : 181 - U124
  • [8] Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
    Ntziachristos, Panagiotis
    Tsirigos, Aristotelis
    Van Vlierberghe, Pieter
    Nedjic, Jelena
    Trimarchi, Thomas
    Flaherty, Maria Sol
    Ferres-Marco, Dolors
    da Ros, Vanina
    Tang, Zuojian
    Siegle, Jasmin
    Asp, Patrik
    Hadler, Michael
    Rigo, Isaura
    De Keersmaecker, Kim
    Patel, Jay
    Tien Huynh
    Utro, Filippo
    Poglio, Sandrine
    Samon, Jeremy B.
    Paietta, Elisabeth
    Racevskis, Janis
    Rowe, Jacob M.
    Rabadan, Raul
    Levine, Ross L.
    Brown, Stuart
    Pflumio, Francoise
    Dominguez, Maria
    Ferrando, Adolfo
    Aifantis, Iannis
    [J]. NATURE MEDICINE, 2012, 18 (02) : 298 - 303
  • [9] An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation
    Souroullas, George P.
    Jeck, William R.
    Parker, Joel S.
    Simon, Jeremy M.
    Liu, Jie-Yu
    Paulk, Joshiawa
    Xiong, Jessie
    Clark, Kelly S.
    Fedoriw, Yuri
    Qi, Jun
    Burd, Christin E.
    Bradner, James E.
    Sharpless, Norman E.
    [J]. NATURE MEDICINE, 2016, 22 (06) : 632 - +
  • [10] EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma
    Yan, Junli
    Li, Boheng
    Lin, Baohong
    Lee, Pei Tsung
    Chung, Tae-Hoon
    Tan, Joy
    Bi, Chonglei
    Lee, Xue Ting
    Selvarajan, Viknesvaran
    Ng, Siok-Bian
    Yang, Henry
    Yu, Qiang
    Chng, Wee-Joo
    [J]. BLOOD, 2016, 128 (07) : 948 - 958
1