The Emerging Role of Non-Coding RNAs in the Regulation of Virus Replication and Resultant Cellular Pathologies

被引：9
作者：
Ghafouri-Fard, Soudeh [1 ]
Hussen, Bashdar Mahmud [2 ,3 ]
Jamal, Hazha Hadayat [4 ]
Taheri, Mohammad [5 ]
Sharifi, Guive [6 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, POB 14155, Tehran, Iran
[2] Hawler Med Univ, Coll Pharm, Dept Pharmacognosy, Erbil 44001, Iraq
[3] Lebanese French Univ, Ctr Res & Strateg Studies, Erbil 44001, Iraq
[4] Salahaddin Univ Erbil, Coll Educ, Dept Biol, Erbil 44001, Iraq
[5] Jena Univ Hosp, Inst Human Genet, Klinikum 1, D-07747 Jena, Germany
[6] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, POB 14155-6153, Tehran, Iran
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 02期
关键词：
long non-coding RNA; miRNA; HSV; EBV; CMV; HSV-1; REPLICATION; GASTRIC-CANCER; MIGRATION; PROLIFERATION; EXPRESSION; MICRORNAS;
D O I：
10.3390/ijms23020815
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Non-coding RNAs, particularly lncRNAs and miRNAs, have recently been shown to regulate different steps in viral infections and induction of immune responses against viruses. Expressions of several host and viral lncRNAs have been found to be altered during viral infection. These lncRNAs can exert antiviral function via inhibition of viral infection or stimulation of antiviral immune response. Some other lncRNAs can promote viral replication or suppress antiviral responses. The current review summarizes the interaction between ncRNAs and herpes simplex virus, cytomegalovirus, and Epstein-Barr infections. The data presented in this review helps identify viral-related regulators and proposes novel strategies for the prevention and treatment of viral infection.
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页数：16
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