Research Progress on The Relationship Between Trimethylamine Oxide and Atherosclerosis

被引：0
|
作者：
Zhang Meng [1 ]
Li Yue [1 ]
Zhang Lei [1 ]
Zhou Ming-Xue [1 ]
Li Si-Nai [1 ]
Liu Wei-Hong [1 ]
机构：
[1] Capital Med Univ, Beijing Inst Tradit Chinese Med, Beijing Hosp Tradit Chinese Med, Beijing 100010, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2022年 / 49卷 / 02期
基金：
北京市自然科学基金;
关键词：
atherosclerosis; trimethylamine oxide; intestinal flora; N-OXIDE; MICROBIAL-METABOLISM; GUT MICROBIOTA; L-CARNITINE; INFLAMMATION; TMAO; PHOSPHATIDYLCHOLINE; MECHANISMS; THROMBOSIS; CHOLINE;
D O I：
10.164767/j.pibb.2021.0088
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cardiovascular and cerebrovascular diseases caused by atherosclerosis (AS) are a kind of diseases that seriously damage human health. In recent years, it has been found that trimethylamine oxide (TMAO), a metabolite of intestinal flora, plays an important role in the pathogenesis of AS: inhibition of cholesterol reverse transport, up regulation of scavenger receptor expression, promotion of foam cell formation, reduction of bile acid pools, enhancement of platelet reactivity, increase of thrombosis risk, damage of vascular endothelium and promotion of inflammatory response. More and more scholars have paid attention to the specific effect and exact mechanism of TMAO on AS. This paper reviews the general characteristics of TMAO, the role of TMAO in the development of AS, and the latest research progress in the prevention and treatment of AS by intervening with TMAO.
引用
收藏
页码：284 / 291
页数：8
相关论文
共 76 条
  • [11] Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial
    Cho, Clara E.
    Taesuwan, Siraphat
    Malysheva, Olga V.
    Bender, Erica
    Tulchinsky, Nathan F.
    Yan, Jian
    Sutter, Jessica L.
    Caudill, Marie A.
    [J]. MOLECULAR NUTRITION & FOOD RESEARCH, 2017, 61 (01)
  • [12] Trimethylamine-N-Oxide: Friend, Foe, or Simply Caught in the Cross-Fire?
    Cho, Clara E.
    Caudill, Marie A.
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2017, 28 (02) : 121 - 130
  • [13] Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
    Craciun, Smaranda
    Balskus, Emily P.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (52) : 21307 - 21312
  • [14] In older women, a high-protein diet including animal-sourced foods did not impact serum levels and urinary excretion of trimethylamine-N-oxide
    Dahl, Wendy J.
    Hung, Wei-Lun
    Ford, Amanda L.
    Suh, Joon Hyuk
    Auger, Jeremie
    Nagulesapillai, Varuni
    Wang, Yu
    [J]. NUTRITION RESEARCH, 2020, 78 : 72 - 81
  • [15] Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
    Ding, Lin
    Chang, Mengru
    Guo, Ying
    Zhang, Lingyu
    Xue, Changhu
    Yanagita, Teruyoshi
    Zhang, Tiantian
    Wang, Yuming
    [J]. LIPIDS IN HEALTH AND DISEASE, 2018, 17
  • [16] Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis
    Fuentes Q, Eduardo
    Fuentes Q, Francisco
    Andres, Vicente
    Pello, Oscar M.
    Font de Mora, Jaime
    Palomo G, Ivan
    [J]. PLATELETS, 2013, 24 (04) : 255 - 262
  • [17] Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine
    Gao, Chongliang
    Catucci, Gianluca
    Castrignano, Silvia
    Gilardi, Gianfranco
    Sadeghi, Sheila J.
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [18] Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway
    Geng, Jin
    Yang, Chenchen
    Wang, Bingjian
    Zhang, Xiwen
    Hu, Tingting
    Gu, Yang
    Li, Ju
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2018, 97 : 941 - 947
  • [19] Apoprotein E and Reverse Cholesterol Transport
    Getz, Godfrey S.
    Reardon, Catherine A.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (11)
  • [20] The complex metabolism of trimethylamine in humans: endogenous and exogenous sources (vol 18, pg e8, 2016)
    Goel, Jyoti Chhibber
    Gaur, Anamika
    Singhal, Varsha
    Parakh, Neeraj
    Bhargava, Balram
    Sharma, Amit
    [J]. EXPERT REVIEWS IN MOLECULAR MEDICINE, 2016, 18
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