The Role of Zinc and Zinc Homeostasis in Macrophage Function

被引：122

作者：

Gao, Hong ^{[1
]}

Dai, Wei ^{[1
]}

Zhao, Lu ^{[1
]}

Min, Junxia ^{[1
]}

Wang, Fudi ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Sch Publ Hlth, Affiliated Hosp 1,Inst Translational Med, Hangzhou 310058, Zhejiang, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2018年 / 2018卷

基金：

中国国家自然科学基金;

关键词：

OXIDE NANOPARTICLES; BACTERIAL CLEARANCE; INFLAMMATORY CYTOKINES; SIGNAL-TRANSDUCTION; MEDIATED INHIBITION; INTRACELLULAR ZINC; TRANSPORTER ZIP14; OXIDATIVE STRESS; TNF-ALPHA; KAPPA-B;

D O I：

10.1155/2018/6872621

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Zinc has long been recognized as an essential trace element, playing roles in the growth and development of all living organisms. In recent decades, zinc homeostasis was also found to be important for the innate immune system, especially for maintaining the function of macrophages. It is now generally accepted that dysregulated zinc homeostasis in macrophages causes impaired phagocytosis and an abnormal inflammatory response. However, many questions remain with respect to the mechanisms that underlie these processes, particularly at the cellular and molecular levels. Here, we review our current understanding of the roles that zinc and zinc transporters play in regulating macrophage function.

引用

页数：11

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