An Efficient Route to Tetrahydroindeno[2,1-b]pyrroles via a Base-Promoted Reaction of (E)-2-Alkynylphenylchalcone with 2-Isocyanoacetate

被引：51

作者：

Zheng, Danqing ^{[1
]}

Li, Shaoyu ^{[1
]}

Luo, Yong ^{[1
]}

Wu, Jie ^{[1
,2
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 24期

基金：

中国国家自然科学基金;

关键词：

DIVERSITY-ORIENTED SYNTHESIS; ORGANIC-SYNTHESIS; CASCADE REACTIONS; MULTICOMPONENT REACTIONS; DOMINO REACTIONS; TANDEM REACTION; CHEMISTRY; CYCLIZATIONS; HETEROCYCLES; ISOCYANIDES;

D O I：

10.1021/ol202708f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A base-promoted cascade reaction of (E)-2-alkynylphenylchalcone with 2-isocyanoacetate provides a novel and efficient route for the synthesis of tetrahydroindeno[2,1-b]pyrroles. The reaction proceeds smoothly in air under mild conditions with high efficiency.

引用

页码：6402 / 6405

页数：4

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