Expression of MMP2 and MMP9 (Gelatinases A and B) in Human Colon Cancer Cells

被引：33
|
作者：
Damodharan, Umadevi [1 ]
Ganesan, Ravikumar [2 ]
Radhakrishnan, Uma C. [2 ]
机构：
[1] Karpagam Arts & Sci Coll, Dept Biochem, Coimbatore 641029, Tamil Nadu, India
[2] Karpagam Univ, Dept Biochem, Coimbatore 641029, Tamil Nadu, India
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2011年 / 165卷 / 5-6期
关键词：
Matrix metalloproteinase; Colon cancer; Emodin; Sodium nitroprusside; Nitric oxide; ANTHRAQUINONES; EMODIN;
D O I：
10.1007/s12010-011-9342-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, collectively capable of degrading essentially all matrix components. Elevated levels of distinct MMPs are detected in tumor tissue or serum of patients with advanced cancer, and they are the major prognostic indicators in cancer. Inhibition of MMPs has been explored as a therapeutic goal for almost two decades. Nitric oxide (NO), a free radical plays an important role in signaling pathways in regulation of MMP expression. In the present study, we demonstrated the role of exogenous NO levels in the regulation of MMP2 and MMP9 (gelatinases A and B) in colon cancer cell line WiDr and its inhibition with emodin (a naturally occurring anthraquinone).
引用
收藏
页码：1245 / 1252
页数：8
相关论文
共 50 条
  • [41] Serum MMP2, MMP7, MMP9 as biomarker prediction of response to treatment and cancer relapse in patients with ovarian cancer
    Song, M. J.
    Lee, Y. S.
    Park, E. K.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2016, 26 : 159 - 159
  • [42] Meta-Analysis of MMP2, MMP3, and MMP9 Promoter Polymorphisms and Head and Neck Cancer Risk
    Zhang, Caiyun
    Li, Chao
    Zhu, Minhui
    Zhang, Qingzhou
    Xie, Zhenghua
    Niu, Gang
    Song, Xicheng
    Jin, Lei
    Li, Guojun
    Zheng, Hongliang
    PLOS ONE, 2013, 8 (04):
  • [43] Fibronectin induces MMP2 expression in human prostate cancer cells
    Moroz, Andrei
    Delella, Flavia K.
    Lacorte, Livia M.
    Deffune, Elenice
    Felisbino, Sergio L.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 430 (04) : 1319 - 1321
  • [44] Role of MMP2 and MMP9 in TRPV4-induced lung injury
    Villalta, Patricia C.
    Rocic, Petra
    Townsley, Mary I.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2014, 307 (08) : L652 - L659
  • [45] Matrix metalloproteinases MMP2 and MMP9 are upregulated by noradrenaline in the mouse neuroendocrine hypothalamus
    Maolood, N.
    Hardin-Pouzet, H.
    Grange-Messent, V.
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 27 (05) : 1143 - 1152
  • [46] MMP2、MMP9在肾癌中的表达及意义
    李泽良
    刘同才
    孙志熙
    王平
    孔垂泽
    温强
    中国医科大学学报, 2001, (04) : 59 - 60+66
  • [47] Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis
    Dang, Alexis B. C.
    Tay, Bobby K. -B.
    Kim, Hubert T.
    Nauth, Aaron
    Alfonso-Jaume, Maria Alexandra
    Lovett, David H.
    SPINE, 2008, 33 (17) : E576 - E579
  • [48] Activity of MMP2 and MMP9 matrix metalloproteinases in patients with myeloproliferative and lymphoproliferative diseases
    Gordiienko, I. A.
    VISNYK OF DNIPROPETROVSK UNIVERSITY-BIOLOGY MEDICINE, 2014, 5 (01): : 54 - 57
  • [49] Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro
    Lelongt, B
    Trugnan, G
    Murphy, G
    Ronco, PM
    JOURNAL OF CELL BIOLOGY, 1997, 136 (06): : 1363 - 1373
  • [50] Mechanical stretch differentially regulates MMP2 and MMP9 activity in the arterial wall
    Lehoux, S
    Mallat, Z
    Merval, R
    Esposito, B
    Tedgui, A
    CIRCULATION, 1998, 98 (17) : 807 - 807
12345