Expression of MMP2 and MMP9 (Gelatinases A and B) in Human Colon Cancer Cells

被引：33

作者：

Damodharan, Umadevi ^{[1
]}

Ganesan, Ravikumar ^{[2
]}

Radhakrishnan, Uma C. ^{[2
]}

机构：

[1] Karpagam Arts & Sci Coll, Dept Biochem, Coimbatore 641029, Tamil Nadu, India

[2] Karpagam Univ, Dept Biochem, Coimbatore 641029, Tamil Nadu, India

来源：

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2011年 / 165卷 / 5-6期

关键词：

Matrix metalloproteinase; Colon cancer; Emodin; Sodium nitroprusside; Nitric oxide; ANTHRAQUINONES; EMODIN;

D O I：

10.1007/s12010-011-9342-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, collectively capable of degrading essentially all matrix components. Elevated levels of distinct MMPs are detected in tumor tissue or serum of patients with advanced cancer, and they are the major prognostic indicators in cancer. Inhibition of MMPs has been explored as a therapeutic goal for almost two decades. Nitric oxide (NO), a free radical plays an important role in signaling pathways in regulation of MMP expression. In the present study, we demonstrated the role of exogenous NO levels in the regulation of MMP2 and MMP9 (gelatinases A and B) in colon cancer cell line WiDr and its inhibition with emodin (a naturally occurring anthraquinone).

引用

页码：1245 / 1252

页数：8

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