The Aging Brain and Neurodegenerative Diseases

被引：25
作者：
Duncan, Gary W. [1 ]
机构：
[1] Meharry Med Coll, Dept Neurol, Nashville, TN 37208 USA
来源：
CLINICS IN GERIATRIC MEDICINE | 2011年 / 27卷 / 04期
关键词：
Aging; Neurodegenerative disease; Alzheimer's disease; Parkinson's disease; Programmed cell death; Apoptosis; Proteinopathies; Mitochondrial dysfunction; Amyloid hypothesis; Biomarkers; Neuroimaging; Risk factors for dementia; MILD COGNITIVE IMPAIRMENT; RANDOMIZED CONTROLLED-TRIAL; INCIDENT ALZHEIMER-DISEASE; C SUPPLEMENT USE; PARKINSONS-DISEASE; VITAMIN-E; DIETARY-INTAKE; MITOCHONDRIAL DYSFUNCTION; PHYSICAL-ACTIVITY; BLOOD-PRESSURE;
D O I：
10.1016/j.cger.2011.07.008
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
This article reviews the current thoughts on the effects of aging on the brain. Mechanisms of neurodegeneration are discussed, particularly those associated with Alzheimer's and Parkinson's diseases. Strategies of early detection of presymptomatic disease and potential future treatments are explored. Modification of risk factors and lifestyles for disease prevention is discussed.
引用
收藏
页码：629 / +
页数：17
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