Regio- and Diastereoselective Spirocyclopropanation of Benzofuran-Derived Azadienes through 1,4-Addition-Induced Dearomatization Reaction under Mild Conditions

被引：38
作者：
Fang, Qing-Yun [1 ]
Yi, Meng-Hao [1 ]
Wu, Xiao-Xia [1 ]
Zhao, Li-Ming [1 ,2 ,3 ]
机构：
[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China
[2] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[3] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 13期
关键词：
CONJUGATE ADDITION; CONSTRUCTION; CYCLOADDITION; ANNULATION; IMINES; ACID;
D O I：
10.1021/acs.orglett.0c01987
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Cs2CO3-mediated [2 + 1] cycloaddition of benzofuran-derived azadienes (BDAs) with bromomalonate by using a dearomatization strategy has been developed. Through this process, BDAs serve as a potential 2-atom synthon in the construction of a range of functionalized spirocyclopropane derivatives, such as spirobenzofuran-2-cyclopropanes and spiroindane-2-cyclopropanes.
引用
收藏
页码：5266 / 5270
页数：5
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