Recent Advances in the Therapeutic Efficacy of Artesunate

被引：52

作者：

Ruwizhi, Ngonidzashe ^{[1
]}

Maseko, Rejoice Bethusile ^{[2
]}

Aderibigbe, Blessing Atim ^{[1
]}

机构：

[1] Univ Ft Hare, Dept Chem, Alice Campus, ZA-5700 Alice, Eastern Cape, South Africa

[2] Sefako Makgatho Hlth Sci Univ, Sch Sci & Technol, Dept Chem, ZA-0208 Ga Rankuwa, Gauteng, South Africa

来源：

PHARMACEUTICS | 2022年 / 14卷 / 03期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

artesunate; malaria; anticancer; tumour; antiviral; COVID-19; skin diseases; FALCIPARUM-MALARIA; ARTEMISININ; COMBINATION; PARASITEMIA; FERROPTOSIS; CLEARANCE; HEMOLYSIS; APOPTOSIS; ANEMIA; CELLS;

D O I：

10.3390/pharmaceutics14030504

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.

引用

页数：23

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