Catalytic asymmetric cleavage of sp3 C-N bonds for access to highly enantioenriched N-benzylic sulfonamides

被引：32

作者：

Wu, Xue-Song ^{[1
]}

Tian, Shi-Kai ^{[1
]}

机构：

[1] Univ Sci & Technol China, Joint Lab Green Synthet Chem, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 06期

基金：

中国国家自然科学基金;

关键词：

FRIEDEL-CRAFTS REACTION; CHIRAL BRONSTED ACID; KINETIC RESOLUTION; CARBON-NITROGEN; ROOM-TEMPERATURE; PHOSPHORIC-ACIDS; ALKYLATION; INDOLES; IMINES; NUCLEOPHILES;

D O I：

10.1039/c1cc16630a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the presence of 10 mol% of a chiral phosphoric acid, a variety of racemic N-benzylic sulfonamides having N-(3-indolyl)methyl groups smoothly undergo kinetic resolution with benzyl thiol at 0 degrees C or at room temperature and the remaining sulfonamides are recovered in moderate to excellent yields and with excellent ee.

引用

页码：898 / 900

页数：3

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