Development of a LC-MS/MS Method for the Determination of Dasatinib in Rat Plasma

被引：0

作者：

Cao, Shan-feng ^{[1
]}

Wang, Xiao-min ^{[1
]}

Zheng, Liu-chuang ^{[2
]}

Sun, Ming ^{[3
]}

Wang, Ying-fei ^{[3
]}

Fan, Rui-tai ^{[1
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

[2] Childrens Hosp Zhengzhou, Zhengzhou Inst Pediat Res, Zhengzhou 450053, Peoples R China

[3] Henan Univ Sci & Technol, Coll Med, Luoyang 471003, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2015年 / 34卷 / 03期

关键词：

dasatinib; LC-MS/MS; pharmacokinetics; rat plasma; TANDEM MASS-SPECTROMETRY; CHRONIC MYELOID-LEUKEMIA; IMATINIB; NILOTINIB; SORAFENIB; LAPATINIB; SUNITINIB; VALIDATION; ERLOTINIB;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, a simple, rapid and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method is described for the determination and pharmacokinetic study of dasatinib in rat plasma samples using imatinib as the internal standard (IS). Sample preparation was accomplished through a simple protein precipitation with acetonitrile, and chromatographic separation was performed on an Acquity BEH C18 column (2.1 mm x 50 mm, 1.7 mu m) with gradient profile at a flow of 0.4 mL/min. The linearity of this method was found to be within the concentration range of 10-1000 ng/mL for dasatinib in rat plasma. Only 4.0 min were needed for an analytical run. The method was applied to a pharmacokinetic study of dasatinib in rats.

引用

页码：542 / 546

页数：5

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