Stability and recovery of DNA origami structure with cation concentration

被引：11
|
作者：
Chen, Yi [1 ]
Wang, Ping [2 ]
Liu, Yang [3 ]
Liu, Ting [1 ]
Xu, Yan [2 ]
Zhu, Shanshan [2 ]
Zhu, Jun [2 ]
Ye, Kai [2 ]
Huang, Guang [4 ]
He Dannong [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China
[2] Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China
[3] Shanghai Tenth Peoples Hosp, Shanghai 200072, Peoples R China
[4] Shanghai Univ Med & Hlth Sci, Shanghai 201318, Peoples R China
来源：
NANOTECHNOLOGY | 2018年 / 29卷 / 03期
关键词：
structural stability; cation concentration; DNA origami; DRUG-DELIVERY; NANOSTRUCTURES; TETRAHEDRON;
D O I：
10.1088/1361-6528/aa9dad
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We synthesized triangular and rectangular DNA origami nanostructures and investigated the stability and recovery of them under low cation concentration. Our results demonstrated that the origami nanostructures would melt when incubated in low cation concentration, and recover whilst kept in the concentration for less than 10 min. However, extending the incubation time would lead to irreversible melting. Our results show the possibility of application of DNA origami nanostructures for things such as a sensor for cation concentration response, etc.
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页数：5
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