Objective: The objective of this study was to compare the clinical efficacy and safety of three kinds of laparoscopic percutaneous high ligation of sac in treating pediatric inguinal hernia, including double-port sledge-shaped Kisschner pin loop method (LPDL-2k), single-port sledge-shaped K isschner pin loop method (LPDL-k), and single-port water injector loop method (LPDL-p). Methods: A total of 396 children with inguinal hernia treated in our pediatric department from January 2013 to April 2015 were enrolled in the study. Among them, 114 patients underwent LPDL-2k, 135 LPDL-k, and 147 LPDL-p. The operation time, intraoperative condition, incidence of postoperative complications, and relapse rate of three groups were compared. Results: For the children with the same gender and the same type of unilateral and bilateral hernia, there was no difference in operation time (P>0.05). About the use of knot pusher in operation, the LPDL-p group had higher using rate than that of the other two groups, with a statistically significant difference (P<0.05). Furthermore, the increase rate of intraoperative trocar of the LPDL-p group was largely less than that of the other two groups, with statistical differences (P<0.05). The incidence of postoperative complications and relapse rate of the children of the LPDL-p group was greatly lower than that of the LPDL-2k group and LPDL-k group, and the difference was statistically significant (P<0.05). Conclusion: LPDL-p has advantages in treating pediatric inguinal hernia than LPDL-2k and LPDL-k, deserving widespread use in the clinic.