Preparation of estriol-molecularly imprinted silica nanoparticles for determining oestrogens in milk tablets

被引：47

作者：

Yuan, Lihua ^{[1
,2
]}

Ma, Jing ^{[1
]}

Ding, Meijuan ^{[1
]}

Wang, Shu ^{[1
]}

Wu, Xiaoli ^{[1
]}

Li, Yun ^{[1
]}

Ma, Kunfang ^{[1
]}

Zhou, Xuemin ^{[1
]}

Li, Fei ^{[1
]}

机构：

[1] Nanjing Med Univ, Sch Pharm, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Nanjing Childrens Hosp, Dept Pharm, Nanjing 210008, Jiangsu, Peoples R China

来源：

FOOD CHEMISTRY | 2012年 / 131卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Estriol; Oestrogens; Silica nanoparticles; Molecularly imprinted polymers; Dispersive solid-phase extraction; Milk tablets; SOLID-PHASE EXTRACTION; CHROMATOGRAPHY-MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; SYNTHETIC ESTROGEN; HUMAN-PLASMA; POLYMER; SURFACE; WATER; 17-ALPHA-ETHINYLESTRADIOL; RECOGNITION;

D O I：

10.1016/j.foodchem.2011.09.090

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this paper, the molecularly imprinted polymer layer of estriol at the silica nanoparticles surface with selective recognition had been constructed. The methacryl groups of functional monomer at the silica nanoparticles surface were acted as reactive sites to induce imprinting polymerisation. The absorption capacity results showed that the molecularly imprinted polymers had an excellent combining affinity, recognition selectivity and fast kinetics. Furthermore, the molecularly imprinted polymers were successfully used as absorbent of dispersive solid-phase extraction coupled with high-performance liquid chromatography to determinate trace estriol and estradiol in milk tablets. The high recoveries yielded of 89.1-93.5% were achieved with the relative standard deviations less than 9.4%. So, the molecularly imprinted polymers are the effective absorbents for the separation and enrichment of oestrogens in the complex matrices samples. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1063 / 1068

页数：6

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