The effect of insulin-like growth factor 1 on the recovery of facial nerve function in a guinea pig model of facial palsy

被引：9

作者：

Sugiyama, Motoyasu ^{[1
]}

Ito, Tsukasa ^{[1
]}

Furukawa, Takatoshi ^{[1
]}

Hirayama, Atsushi ^{[2
]}

Kakehata, Seiji ^{[1
]}

机构：

[1] Yamagata Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, 2-2-2 Iida Nishi, Yamagata, Yamagata 9909585, Japan

[2] Osaka Univ, Grad Sch Med, Dept Social Med, Publ Hlth, 2-15 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF PHYSIOLOGICAL SCIENCES | 2020年 / 70卷 / 01期

关键词：

Peripheral facial nerve palsy; Insulin-like growth factor 1; Electroneurography; Physiological function; Gelatin-based hydrogel; HERPES-SIMPLEX-VIRUS; FACTOR-I; BELLS-PALSY; REGENERATION; INJURY; IGF-1; REACTIVATION; COMPRESSION; RECEPTOR; SURGERY;

D O I：

10.1186/s12576-020-00755-0

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The efficacy of insulin-like growth factor 1 (IGF-1) in the treatment of peripheral facial nerve palsy was investigated using an animal model. The facial nerve within the temporal bone was exposed and compressed by clamping. The animals were treated with either IGF-1 or saline which was topically administered by a gelatin-based sustained-release hydrogel via an intratemporal route. The recovery from facial nerve palsy was evaluated at 8 weeks postoperatively based on eyelid closure, complete recovery rate, electroneurography and number of axons found on the facial nerve. IGF-1 treatment resulted in significant improvement in the changes of the degree of eyelid closure over the total time period and complete recovery rate. A separate study showed that IGF-1 receptor mRNA was expressed in facial nerves up to 14 days after the nerve-clamping procedure. IGF-1 was thus found to be effective in the treatment of peripheral facial nerve palsy when topically applied using a sustained-release gelatin-based hydrogel via an intratemporal route.

引用

页数：13

共 52 条

[1] Adipose-Derived Stem Cells Enhance Axonal Regeneration through Cross-Facial Nerve Grafting in a Rat Model of Facial Paralysis [J].