MiR-125a Is a critical modulator for neutrophil development

被引：23

作者：

Qin, Yuting ^{[1
,2
]}

Wu, Lingling ^{[1
,2
]}

Ouyang, Ye ^{[1
,2
]}

Zhou, Ping ^{[1
,2
]}

Zhou, Haibo ^{[1
,2
]}

Wang, Yan ^{[3
,4
]}

Ma, Jianyang ^{[1
,2
]}

Zhang, Jinsong ^{[3
,4
]}

Chen, Yanan ^{[1
,2
]}

Qian, Jie ^{[1
,2
]}

Tang, Yuanjia ^{[1
,2
]}

Shen, Nan ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Dept Rheumatol, Renji Hosp, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Rheumatol, Renji Hosp, Shanghai, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China

[5] Renji Hosp, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Med, Collaborat Innovat Ctr Translat Med, Shanghai, Peoples R China

[7] Cincinnati Childrens Hosp Med Ctr, CAGE, Cincinnati, OH 45229 USA

[8] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, China Australia Ctr Personalised Immunol, Shanghai, Peoples R China

来源：

PLOS GENETICS | 2017年 / 13卷 / 10期

基金：

中国国家自然科学基金;

关键词：

COLONY-STIMULATING FACTOR; PHYSIOLOGICAL NEGATIVE REGULATOR; TRANSCRIPTION FACTOR; MICRORNA CONTROL; GRANULOCYTE; SOCS3; DIFFERENTIATION; PROLIFERATION; MECHANISM;

D O I：

10.1371/journal.pgen.1007027

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

MicroRNAs are universal post-transcriptional regulators in genomes. They have the ability of buffering gene expressional programs, contributing to robustness of biological systems and playing important roles in development, physiology and diseases. Here, we identified a microRNA, miR-125a, as a positive regulator of granulopoiesis. MiR125a knockout mice show reduced infiltration of neutrophils in the lung and alleviated tissue destruction after endotoxin challenge as a consequence of decreased neutrophil numbers. Furthermore, we demonstrated that this significant reduction of neutrophils was due to impaired development of granulocyte precursors to mature neutrophils in an intrinsic manner. We showed that Socs3, a critical repressor for granulopoiesis, was a target of miR-125a. Overall, our study revealed a new microRNA regulating granulocyte development and supported a model in which miR-125a acted as a fine-tuner of granulopoiesis.

引用

页数：22

共 39 条

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