Inhibitory Effect of Citrus Peel Extract on Lipid Accumulation of 3T3-L1 Adipocytes

被引：15

作者：

Jung, Hee Kyung ^{[2
]}

Jeong, Yoo Seok ^{[2
]}

Park, Chi-Duck ^{[2
]}

Park, Chang-Ho ^{[2
]}

Hong, Joo-Heon ^{[1
]}

机构：

[1] Catholic Univ Daegu, Dept Food Sci & Technol, Gyongsan 712702, South Korea

[2] Daegu Technopk, Bio Ind Ctr, Taegu 704701, South Korea

来源：

JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2011年 / 54卷 / 02期

关键词：

adipocyte; citrus peel extract; hesperidin; perilipin; real time-polymerase chain reaction; BINDING PROTEIN; DIFFERENTIATION; ADIPOGENESIS; OBESITY; APOPTOSIS; LIPOLYSIS; DROPLETS; INSULIN; PLASMA;

D O I：

10.3839/jksabc.2011.028

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Inhibitory effects of lipid accumulation by citrus peel extract were evaluated. Citrus peel extract (CPE) (500 mu g/mL) inhibited lipid and triglyceride accumulation in 3T3-L1 adipocytes by more than 64.5 and 58.7%, respectively and suppressed glycerol-3-phosphate dehydrogenase to the levels of preadipocytes. The expression of perilipin mRNA in 3T3-L1 adipocytes treated with CPE was significantly lower than that in untreated adipocytes (p<0.05), with no accompanying increase in lipolysis-related mRNA. Flavonoid compositions of CPE were hesperidin 13.79, narirutin 7, and naringin 262.5 mu g/g, respectively. These findings suggest CPE may indirectly stimulate lipolysis by inhibiting protection of physical barrier on lipid droplet to hinder lipid accumulation in 3T3-L1 adipocytes.

引用

页码：169 / 176

页数：8

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