TCF7L2 alleles and metabolic syndrome in non-diabetic obese hypertensive patients

被引：5

作者：

Sarzani, R. ^{[1
]}

Salvi, F. ^{[1
]}

Bordicchia, M. ^{[1
]}

Pietrucci, F. ^{[1
]}

Caraceni, D. ^{[1
]}

Lancioni, L. ^{[1
]}

Dessi-Fulgheri, P. ^{[1
]}

Rappelli, A. ^{[1
]}

机构：

[1] Univ Ancona Politecn Marche, Dept Internal Med, Ancona, Italy

来源：

JOURNAL OF HUMAN HYPERTENSION | 2008年 / 22卷 / 05期

关键词：

D O I：

10.1038/jhh.2008.8

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Obese hypertensive (OH) patients carrying TCF7L2 alleles predisposing to type 2 diabetes (T2D) may have a further increase in 'cardiometabolic' risk; therefore, we studied 204 OH patients (<65 years old) without T2D and 222 unselected adults to verify TCF7L2 allele frequencies and investigate the metabolic phenotype. Allele and genotype distribution between OH patients and controls was not different, whereas OH patients with metabolic syndrome (MetS) had a higher frequency of allele X than those without MetS (66.2 vs 40%, P = 0.006). TCF7L2 DG10S478 X and rs7903146 T alleles may identify OH patients with further increased risk of developing T2D and DG10S478 X associated with, and may predispose OH to, MetS.

引用

页码：373 / 375

页数：3

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