One-pot synthesis of benzo[b]thiophenes and naphtho[2,1-b]thiophenes in the presence of acidic and basic supported reagents

被引：9

作者：

Aoyama, T

Takido, T

Kodomari, M

机构：

[1] Nihon Univ, Coll Sci & Technol, Dept Mat & Appl Chem, Chiyoda Ku, Tokyo 1018308, Japan

[2] Shibaura Inst Technol, Dept Appl Chem, Minato Ku, Tokyo 1088548, Japan

来源：

SYNLETT | 2005年 / 18期

关键词：

one-pot synthesis; benzo[b]thiophenes; naphtho[2,1-b]thiophenes; supported reagents;

D O I：

10.1055/s-2005-918928

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method has been developed for the synthesis of benzo[b]thiophenes and naplitho[2, 1-b]thioplienes from aryl thiols and a-halo ketones by using an acid- and a base-supported reagent system, Na2CO3/SiO2-PPA/SiO2. Reaction of alpha-halo ketones with aryl thiols is promoted by Na2CO3/SiO2 to afford a-phenylthio ketones, which cyclizes in the presence of PPA/SiO2 to give the corresponding arylthioplienes in one-pot.

引用

收藏

页码：2739 / 2742

页数：4

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