Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya

被引：66

作者：

Midega, Janet T. ^{[1
,2
]}

Smith, Dave L. ^{[3
,4
]}

Olotu, Ally ^{[1
]}

Mwangangi, Joseph M. ^{[1
]}

Nzovu, Joseph G. ^{[1
]}

Wambua, Juliana ^{[1
]}

Nyangweso, George ^{[1
]}

Mbogo, Charles M. ^{[1
]}

Christophides, George K. ^{[2
]}

Marsh, Kevin ^{[1
,5
]}

Bejon, Philip ^{[1
,5
]}

机构：

[1] Ctr Geog Med Res Coast, KEMRI Wellcome Trust Collaborat Res Programme, Kilifi 80108, Kenya

[2] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[4] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

[5] Univ Oxford, Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England

来源：

NATURE COMMUNICATIONS | 2012年 / 3卷

基金：

美国国家卫生研究院;

关键词：

ENTOMOLOGICAL INOCULATION RATE; ANOPHELES-GAMBIAE; TRANSMISSION; MOSQUITOS; CHILDREN; COAST; VILLAGE; AREA; EPIDEMIOLOGY; PHILIPPINES;

D O I：

10.1038/ncomms1672

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies of the fine-scale spatial epidemiology of malaria consistently identify malaria hotspots, comprising clusters of homesteads at high transmission intensity. These hotspots sustain transmission, and may be targeted by malaria-control programmes. Here we describe the spatial relationship between the location of Anopheles larval sites and human malaria infection in a cohort study of 642 children, aged 1-10-years-old. Our data suggest that proximity to larval sites predict human malaria infection, when homesteads are upwind of larval sites, but not when homesteads are downwind of larval sites. We conclude that following oviposition, female Anophelines fly upwind in search for human hosts and, thus, malaria transmission may be disrupted by targeting vector larval sites in close proximity, and downwind to malaria hotspots.

引用

页数：8

共 43 条

[1] Anopheles gambiae: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya [J].

Bayoh, M. Nabie ;

Mathias, Derrick K. ;

Odiere, Maurice R. ;

Mutuku, Francis M. ;

Kamau, Luna ;

Gimnig, John E. ;

Vulule, John M. ;

Hawley, William A. ;

Hamel, Mary J. ;

Walker, Edward D. .

MALARIA JOURNAL, 2010, 9

[2] A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya [J].

Bejon, Philip ;

Mwacharo, Jedidah ;

Kai, Oscar ;

Mwangi, Tabitha ;

Milligan, Paul ;

Todryk, Stephen ;

Keating, Sheila ;

Lang, Trudie ;

Lowe, Brett ;

Gikonyo, Caroline ;

Molyneux, Catherine ;

Fegan, Greg ;

Gilbert, Sarah C. ;

Peshu, Norbert ;

Marsh, Kevin ;

Hill, Adrian V. S. .

PLOS CLINICAL TRIALS, 2006, 1 (06)

[3] Stable and Unstable Malaria Hotspots in Longitudinal Cohort Studies in Kenya [J].

Bejon, Philip ;

Williams, Thomas N. ;

Liljander, Anne ;

Noor, Abdisalan M. ;

Wambua, Juliana ;

Ogada, Edna ;

Olotu, Ally ;

Osier, Faith H. A. ;

Hay, Simon I. ;

Farnert, Anna ;

Marsh, Kevin .

PLOS MEDICINE, 2010, 7 (07)

[4] Interactions between Age and ITN Use Determine the Risk of Febrile Malaria in Children [J].

Bejon, Philip ;

Ogada, Edna ;

Peshu, Norbert ;

Marsh, Kevin .

PLOS ONE, 2009, 4 (12)

[5] Field epidemiological studies on malaria in a low endemic area in the Philippines [J].

Belizario, VY ;

Saul, A ;

Bustos, MDG ;

Lansang, MA ;

Pasay, CJ ;

Gatton, M ;

Salazar, NP .

ACTA TROPICA, 1997, 63 (04) :241-256

[6] Permethrin-impregnated bednet effects on resting and feeding behaviour of lymphatic filariasis vector mosquitoes in Kenya [J].

Bogh, C ;

Pedersen, EM ;

Mukoko, DA ;

Ouma, JH .

MEDICAL AND VETERINARY ENTOMOLOGY, 1998, 12 (01) :52-59

[7] Identification of Hot Spots of Malaria Transmission for Targeted Malaria Control [J].

Bousema, Teun ;

Drakeley, Chris ;

Gesase, Samwel ;

Hashim, Ramadhan ;

Magesa, Stephen ;

Mosha, Frank ;

Otieno, Silas ;

Carneiro, Ilona ;

Cox, Jonathan ;

Msuya, Eliapendavyo ;

Kleinschmidt, Immo ;

Maxwell, Caroline ;

Greenwood, Brian ;

Riley, Eleanor ;

Sauerwein, Robert ;

Chandramohan, Daniel ;

Gosling, Roly .

JOURNAL OF INFECTIOUS DISEASES, 2010, 201 (11) :1764-1774

[8] Serologic Markers for Detecting Malaria in Areas of Low Endemicity, Somalia, 2008 [J].

Bousema, Teun ;

Youssef, Randa M. ;

Cook, Jackie ;

Cox, Jonathan ;

Alegana, Victor A. ;

Amran, Jamal ;

Noor, Abdisalan M. ;

Snow, Robert W. ;

Drakeley, Chris .

EMERGING INFECTIOUS DISEASES, 2010, 16 (03) :392-399

[9] Changes in malaria indices between 1999 and 2007 in The Gambia: a retrospective analysis [J].

Ceesay, Serign J. ;

Casals-Pascual, Climent ;

Erskine, Jamie ;

Anya, Samuel E. ;

Duah, Nancy O. ;

Fulford, Anthony J. C. ;

Sesay, Sanie S. S. ;

Abubakar, Ismaela ;

Dunyo, Samuel ;

Sey, Omar ;

Palmer, Ayo ;

Fofana, Malang ;

Corrah, Tumani ;

Bojang, Kalifa A. ;

Whittle, Hilton C. ;

Greenwood, Brian M. ;

Conway, David J. .

LANCET, 2008, 372 (9649) :1545-1554

[10] Risk of malaria attacks in Gambian children is greater away from malaria vector breeding sites [J].

Clarke, SE ;

Bogh, C ;

Brown, RC ;

Walraven, GEL ;

Thomas, CJ ;

Lindsay, SW .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2002, 96 (05) :499-506

← 1 2 3 4 5 →