Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling

被引：207

作者：

Tu, Hai-Yong ^{[1
]}

Wang, Fang ^{[1
]}

Huo, Liping ^{[1
]}

Li, Yuanbo ^{[1
]}

Zhu, Shengqing ^{[1
]}

Zhao, Xian ^{[1
]}

Li, Huan ^{[1
]}

Qing, Feng-Ling ^{[1
]}

Chu, Lingling ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Ctr Adv Low Dimens Mat, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 20620, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 21期

基金：

中国国家自然科学基金;

关键词：

REDUCTIVE DICARBOFUNCTIONALIZATION; ARYL-ALKENYLATION; FUNCTIONALIZATION; PHOTOREDOX; ARYLATION; FLUORINE; ALKENES; ACCESS;

D O I：

10.1021/jacs.0c03708

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nickel-catalyzed, enantioselective, three-component fluoroalkylarylation of unactivated alkenes with aryl halides and perfluoroalkyl iodides has been described. This cross-electrophile coupling protocol utilizes a chiral nickel/BiOx system as well as a pendant chelating group to facilitate the challenging three-component, asymmetric difunctionalization of unactivated alkenes, providing direct access to valuable chiral beta-fluoroalkyl arylalkanes with high efficiency and excellent enantioselectivity. The mild conditions allow for a broad substrate scope as well as good functional group toleration.

引用

页码：9604 / 9611

页数：8

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