Lyophilised protein dynamics: more than just methyls?

被引：12

作者：

Telling, Mark T. F. ^{[1
,2
]}

Clifton, Luke ^{[1
]}

Combet, Jerome ^{[3
]}

Frick, Bernhard ^{[3
]}

Howells, Spencer ^{[1
]}

Sakai, Victoria Garcia ^{[1
]}

机构：

[1] Rutherford Appleton Lab, ISIS Facil, Rutherford, NJ USA

[2] Univ Oxford, Dept Mat, Oxford OX1 3PH, England

[3] Inst Max Von Laue Paul Langevin, F-38042 Grenoble, France

来源：

SOFT MATTER | 2012年 / 8卷 / 37期

关键词：

NEUTRON-SCATTERING MEASUREMENTS; TEMPERATURE-DEPENDENCE; MULTISUBUNIT PROTEIN; APOFERRITIN;

D O I：

10.1039/c2sm26540k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Neutron spectroscopy has been used to probe picosecond to nanosecond dynamics in lyophilised apoferritin, insulin, superoxide dismutase and green fluorescent protein. These proteins have markedly different secondary structures yet similar CH3 compositions. Results suggest that while only CH3 activation is apparent in apoferritin, an enhanced dynamic environment presents itself in Ins, SOD and GfP. Our results hint at a structure dependent dynamic landscape.

引用

页码：9529 / 9532

页数：4

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