A new prognostic staging system for hepatocellular carcinoma: Value of the biomarker combined Japan Integrated Staging score

被引：33

作者：

Kitai, Satoshi ^{[1
]}

Kudo, Masatoshi ^{[1
]}

Minami, Yasunori ^{[1
]}

Ueshima, Kazuomi ^{[1
]}

Chung, Hobyung ^{[1
]}

Hagiwara, Satoru ^{[1
]}

Inoue, Tatsuo ^{[1
]}

Ishikawa, Emi ^{[1
]}

Takahashi, Shunsuke ^{[1
]}

Asakuma, Yutaka ^{[1
]}

Haji, Seiji ^{[2
]}

Osaki, Yukio ^{[3
]}

Oka, Hiroko ^{[4
]}

Seki, Toshihito ^{[5
]}

Kasugai, Hiroshi ^{[6
]}

Sasaki, Yo ^{[7
]}

Matsunaga, Takashi ^{[8
]}

机构：

[1] Kinki Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Osaka 5898511, Japan

[2] Kinki Univ, Sch Med, Dept Surg, Osaka 5898511, Japan

[3] Osaka Red Cross Hosp, Dept Gastroenterol, Osaka, Japan

[4] Osaka City Gen Hosp, Dept Gastroenterol, Osaka, Japan

[5] Kansai Med Univ, Dept Gastroenterol & Hepatol, Osaka, Japan

[6] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Gastroenterol, Osaka, Japan

[7] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Surg, Osaka, Japan

[8] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Clin Lab & Med Informat, Osaka, Japan

来源：

INTERVIROLOGY | 2008年 / 51卷

关键词：

AFP-L3; biomarkers; des-gamma-carboxy prothrombin; alpha-fetoprotein; Japan Integrated Staging score; Lens culinaris;

D O I：

10.1159/000122599

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Objectives: The Japan Integrated Staging (JIS) score has been reported to have good stratification ability in patients with hepatocellular carcinoma (HCC). However, the JIS score could not estimate malignant grade of HCC. The aim of this study was to evaluate the performance of a new staging system: the biomarker combined JIS (bm-JIS) which includes three tumor markers: alpha-fetoprotein (AFP), Lens culinaris agglutininreactive AFP and des-gamma-carboxy prothrombin with the conventional JIS score. Methods: A total of 1,924 HCC patients were included in this study. We compared their overall survival, the stratification ability and suitability as a prognostic model according to the bm-JIS score and the conventional JIS score. Results: There were significant differences between the survival curves for all bm-JIS scores. For the conventional JIS scores of 0, 1, 2 and 3, the survival curves differed greatly according to the bm-JIS score ( p < 0.0001). The independent homogenizing ability and the stratification value of the JIS score and the bm-JIS score determined by the likelihood ratio test using the Cox proportional hazard regression model showed the bm- JIS score to have a higher value (chi(2) = 717.348) than the JIS score (chi(2) = 668.91). Conclusions: The bm- JIS score showed superior stratification ability and thus was found to be a better predictor of the prognosis than the conventional JIS score, especially for the patients with good prognosis. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：86 / 94

页数：9

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