The major genetic risk factor for severe COVID-19 is associated with protection against HIV

被引：18

作者：

Zeberg, Hugo ^{[1
,2
]}

机构：

[1] Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany

[2] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2022年 / 119卷 / 09期

基金：

瑞典研究理事会;

关键词：

COVID-19; HIV; genetics; RECEPTORS; SMALLPOX; CCR5;

D O I：

10.1073/pnas.2116435119

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative, Nature 600, 472-477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Paeuroaeurobo, Nature 587, 610-612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an similar to 27% lower risk of HIV infection.

引用

页数：3

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