Down-regulation of AQP4 Inhibits Proliferation, Migration and Invasion of Human Breast Cancer Cells

被引：0
作者：
Li, Y-B. [1 ]
Sun, S-R. [1 ]
Han, X-H. [2 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Wuhan 430060, Peoples R China
[2] Inner Mongolia Peoples Hosp, Hohhot, Peoples R China
来源：
FOLIA BIOLOGICA | 2016年 / 62卷 / 03期
关键词：
breast cancer; AQP4; siRNA; E-cadherin; ERK pathway; MEDIATED REGULATION; P120; CATENIN; AQUAPORINS; APOPTOSIS; EXPRESSION; GROWTH; BETA;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aquaporins (AQPs), proteinaceous water channels, have been proposed as mediators of tumour development and progression. However, the role of aquaporin 4 (AQP4), a member of the AQP family, in breast cancer has not been distinctly evaluated. The aim of the present study was to examine the effect of AQP4 down-regulation on proliferation, migration and invasion in human breast cancer. To determine this effect, siRNA interference was used to knock down its expression in T47D and MCF-7 cell lines. Down-regulation of AQP4 resulted in increased expression of E-cadherin along with an inhibitory effect on the proliferation, migration and invasion in breast cancer cells. In addition, AQP4 regulation of cell proliferation could be related with the ERK/E-cadherin pathway. In conclusion, the present data have suggested that down-regulation of AQP4 inhibits breast cancer cell proliferation, migration and invasion.
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收藏
页码：131 / 137
页数：7
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