Evaluation of haemostasis in children treated with valproic acid

被引：4

作者：

Schaedlich, D. ^{[1
]}

Friebel, D. ^{[2
]}

Schallner, J. ^{[2
]}

Gehrisch, S. ^{[3
]}

Siegert, G. ^{[3
]}

Kuhlisch, E. ^{[4
]}

Knoefler, R. ^{[1
]}

机构：

[1] Univ Klinikum Carl Gustav Carus Dresden, Klin & Poliklin Kinder & Jugendmed, Bereich Hamatol Onkol Hamostaseol, D-10309 Dresden, Germany

[2] Univ Klinikum Carl Gustav Carus Dresden, Klin & Poliklin Kinder & Jugendmed, Abt Neuropadiat, D-10309 Dresden, Germany

[3] Univ Klinikum Carl Gustav Carus Dresden, Inst Klin Chem & Labs Med, D-10309 Dresden, Germany

[4] Univ Klinikum Carl Gustav Carus Dresden, Inst Med Informat, D-10309 Dresden, Germany

来源：

HAMOSTASEOLOGIE | 2010年 / 30卷 / 4A期

关键词：

Valproic acid; haemostasis; children; THERAPY;

D O I：

10.1055/s-0037-1619094

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coagulation parameters were determined in children with valproic acid mono- and valproic acid-lamotrigin combination therapy. Patients, methods: Monotherapy group (n = 22; mean age: 10.5 years) was compared to combination therapy (n = 7; 12.9 years) and a control group (n = 22; 8.7 years). The following parameters were measured: aggregation and ATP-release in whole blood (ADP: 20 mu mol/1, collagen: 1 mu g/ml, thrombin: 0.5 U/ml), PFA-100 (R) closure times (CT), blood cell counts, global tests, VWF : Ag, VWF : CBA, factors VIII and XIII as well as fibrinogen. Bleeding symptoms were evaluated by using a questionnaire. Results: For ADP- and collagen-induced aggregation as well as for ATP release no significant differences between the groups were detected. The combined therapy group showed significantly prolonged CT.Von Willebrand disease was not detected in any of the patients. The platelet count was significantly decreased in the monotherapy group. In six children a mild bleeding tendency was observed, mostly epistaxis. Conclusion: A clinically relevant influence of valproic acid on haemostasis was found only in few cases. However, before surgical procedures an extended coagulation diagnostics is recommended in patients with valproic acid therapy.

引用

页码：S132 / S137

页数：6

共 20 条

[1] Pro- and anticoagulatory factors under sodium valproate-therapy in children [J].