Visible light-induced phosphine-catalyzed perfluoroalkylation of indoles

被引：16

作者：

Gao, Xiuhui ^{[1
]}

Pan, Xuling ^{[1
]}

Wang, Peiyi ^{[1
]}

Jin, Zhichao ^{[1
]}

机构：

[1] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 21期

基金：

中国国家自然科学基金;

关键词：

BIOLOGICAL-ACTIVITIES; OXIDATIVE TRIFLUOROMETHYLATION; RADICAL REACTIONS; FLUORINE; ALKENES; DESIGN; PHARMACEUTICALS; HETEROCYCLES; INHIBITORS; IODIDES;

D O I：

10.1039/d2qo01091g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A photo-induced, catalytic phosphine-promoted perfluoroalkylation reaction of indole molecules is developed. Inexpensive and readily available PPh3 is used in a catalytic amount as the sole reaction initiator in this protocol. Indole molecules bearing various substitution patterns and biologically significant fragments work well in this strategy, with the perfluoroalkylated products obtained in moderate to excellent yields. Several of the obtained F-containing indole products exhibited good anti-bacterial activities against plant pathogens and can be regarded as promising lead structures in the development of novel pesticides.

引用

页码：5790 / 5797

页数：8

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