Nano-SnCl4/SiO2 as a Catalyst for One-Pot Synthesis of Substituted 1H-Pyrazoles as Antifungal and Cytotoxic Agents

被引：3

作者：

Khabnadideh, Soghra ^{[1
]}

Faghih, Zeinab ^{[1
]}

Zamani, Leila ^{[1
]}

Zomorodian, Kamiar ^{[2
,3
]}

Mirjalili, Bi Bi Fatemesh ^{[4
]}

Moradi, Hadi ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran

[2] Shiraz Univ Med Sci, Sch Med, Ctr Basic Res Infect Dis, Shiraz, Iran

[3] Shiraz Univ Med Sci, Sch Med, Dept Med Mycol & Parasitol, Shiraz, Iran

[4] Yazd Univ, Coll Sci, Dept Chem, POB 89195-741, Yazd, Iran

来源：

LETTERS IN ORGANIC CHEMISTRY | 2020年 / 17卷 / 06期

关键词：

Pyrazole; Nano-SnCl4/SiO2; antifungal; antibacterial; cytotoxic activity; antimicrobial activities; MOLECULAR DOCKING; PYRAZOLE; DERIVATIVES;

D O I：

10.2174/1570178617666191127104622

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method was developed for the synthesis of pyrazole derivatives via a one-pot reaction of 1,3-diketone and substituted hydrazines in the presence of nano-SnCl4/SiO2 as a mild catalyst. A series of some pyrazole derivatives (P1-P11) was synthesized and evaluated as antifungal and anti-cancer agents. Compounds P10 and P11 were demonstrated. The antimicrobial activities of the synthetic compounds showed that compounds P10 and P11 most excellently inhibited the growth of dermatophytes or Aspergillus species, respectively. Therefore, the cytotoxic activities of these compounds on two human cancer cell lines, A549 (lung cancer) and MCF-7 (breast cancer) were further assessed. Hence, results demonstrated that beside antifungal activity, P10 had also desirable cytotoxic effect on investigated cancerous cell lines, even higher than cisplatin.

引用

页码：459 / 465

页数：7