A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia

被引：62

作者：

Such, Esperanza ^{[1
]}

Cervera, Jose ^{[1
]}

Valencia, Ana ^{[1
]}

Barragan, Eva ^{[2
]}

Ibanez, Mariam ^{[1
]}

Luna, Irene ^{[1
]}

Fuster, Oscar ^{[2
]}

Luz Perez-Sirvent, Maria ^{[1
]}

Senent, Leonor ^{[1
]}

Sempere, Amparo ^{[1
]}

Martinez, Jesus ^{[1
]}

Martin-Aragones, Guillermo ^{[1
]}

Sanz, Miguel A. ^{[1
]}

机构：

[1] Hosp Univ La Fe, Dept Hematol, Valencia 46009, Spain

[2] Hosp Univ La Fe, Dept Med Pathol, Valencia 46009, Spain

来源：

BLOOD | 2011年 / 117卷 / 01期

关键词：

RETINOIC ACID; T(11/12)(P15; Q13); PML;

D O I：

10.1182/blood-2010-06-291658

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative genomic hybridization array as the retinoid acid receptor gamma gene (RARG). The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia. (Blood. 2011;117(1):242-245)

引用

页码：242 / 245

页数：4

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