Current perspective on the regulation of FOXO4 and its role in disease progression

被引：75

作者：

Liu, Wen ^{[1
]}

Li, Yong ^{[2
,3
]}

Luo, Bing ^{[1
]}

机构：

[1] Qingdao Univ, Fac Med, Dept Pathogen Biol, Qingdao, Peoples R China

[2] Qingdao Univ, Shandong Prov Key Lab Pathogenesis & Prevent Neur, Dept Physiol, Qingdao, Peoples R China

[3] Qingdao Univ, State Key Disciplines Physiol, Fac Med, Qingdao, Peoples R China

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2020年 / 77卷 / 04期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

FOXO4; Cell proliferation; Apoptosis; Cancer; Drug response; FORKHEAD TRANSCRIPTION FACTORS; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; DOWN-REGULATION; FACTOR AFX; MITOCHONDRIAL DYSFUNCTION; SIGNALING PATHWAYS; GENE-EXPRESSION; PROMOTES; APOPTOSIS;

D O I：

10.1007/s00018-019-03297-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Forkhead box O4 (FOXO4) is a member of the FOXO family that regulates a number of genes involved in metabolism, cell cycle, apoptosis, and cellular homeostasis via transcriptional activity. It also mediates cell responses to oxidative stress and treatment with antitumor agents. The expression of FOXO4 is repressed by microRNAs in multiple cancer cells, while FOXO4 function is regulated by post-translational modifications and interaction with other proteins. The deregulation of FOXO4 is closely linked to the progression of several types of cancer, senescence, and other diseases. In this review, we present recent findings on the regulation of FOXO4 in physiological and pathological conditions and provide an overview of the complex role of FOXO4 in disease development and response to therapy.

引用

页码：651 / 663

页数：13

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