The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

被引：21
作者：
Singh, Kanika [1 ]
Nassar, Nazim [2 ]
Bachari, Ava [1 ]
Schanknecht, Ellen [1 ]
Telukutla, Srinivasareddy [1 ]
Zomer, Roby [3 ]
Piva, Terrence J. [2 ]
Mantri, Nitin [1 ,4 ]
机构：
[1] RMIT Univ, Sch Sci, Pangen Lab, Bundoora, Vic 3083, Australia
[2] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia
[3] MGC Pharmaceut Ltd, Perth, WA 6005, Australia
[4] Univ Western Australia, UWA Inst Agr, Perth, WA 6009, Australia
来源：
CANCERS | 2021年 / 13卷 / 16期
关键词：
prostate cancer; cannabis; cannabinoids; cannabinoid receptors; cancer; RECEPTOR TYROSINE KINASES; INDUCED APOPTOSIS; OXIDATIVE STRESS; CELL-DEATH; IN-VITRO; CB1; ACTIVATION; ENDOCANNABINOIDS; EPIDEMIOLOGY; STIMULATION;
D O I：
10.3390/cancers13164107
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their possible mechanisms of action in prostate cancer. Besides the palliative effects of cannabinoids, research from the past two decades has demonstrated their promising potential as antitumor agents in a wide variety of cancers. This analysis may provide pharmacological insights into the selection of specific cannabinoids for the development of antitumor drugs for the treatment of prostate cancer.
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页数：18
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