Synthesis and antimicrobial evaluation of novel pyrazolo[1,5-a]pyrimidine, triazolo[1,5-a]pyrimidine and pyrimido[1,2-a]benzimidazole derivatives

被引：0

作者：

Shaaban, Mohamed R. ^{[1
]}

Saleh, Tamer S. ^{[1
]}

Farag, Ahmad M. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt

来源：

HETEROCYCLES | 2007年 / 71卷 / 08期

关键词：

2-acetylbenzimidazole; pyrazolo[1,5-a]pyrimidine; triazolo[1,5-a]pyrimidine; pyrimido[1,2-a]benzimidazole; antimicrobiol activity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The applicability and synthetic potency of E-1-(1-methylbenzimidazol-2-yl)-3-N,N-dimethylaminoprop-2-enone towards some nitrogen nucleophiles was investigated as a convenient route for the synthesis of some novel aminopyrimidine, pyrazolo[1,5-a]pyrimidine, triazolo[1,5-a]pyrimidine, pyrimido[1,2-a]benzimidazole, and pyrido[2,3-d]pyrimidine derivatives. Some of the newly synthesized compounds were tested in vitro for their antibacterial and antifungal activities, and showed promising results.

引用

页码：1765 / 1777

页数：13

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