Does Longer Lifespan Mean Longer Healthspan?

被引:74
作者
Hansen, Malene [1 ]
Kennedy, Brian K. [2 ]
机构
[1] Sanford Burnham Prebys Med Res Inst, La Jolla, CA 92037 USA
[2] Buck Inst Res Aging, Novato, CA 94945 USA
关键词
D O I
10.1016/j.tcb.2016.05.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Once thought to be impossible, it is now clear that changing the activity of several conserved genetic pathways can lead to lifespan extension in experimental organisms. In humans, however, the goal is to extend healthspan, the functional and disease-free period of life. Are the current pathways to lifespan extension also improving healthspan?
引用
收藏
页码:565 / 568
页数:4
相关论文
共 15 条
  • [1] Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants
    Bansal, Ankita
    Zhu, Lihua J.
    Yen, Kelvin
    Tissenbaum, Heidi A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (03) : E277 - E286
  • [2] Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
    Dai, Dao-Fu
    Karunadharma, Pabalu P.
    Chiao, Ying A.
    Basisty, Nathan
    Crispin, David
    Hsieh, Edward J.
    Chen, Tony
    Gu, Haiwei
    Djukovic, Danijel
    Raftery, Daniel
    Beyer, Richard P.
    MacCoss, Michael J.
    Rabinovitch, Peter S.
    [J]. AGING CELL, 2014, 13 (03): : 529 - 539
  • [3] Ageing and protein aggregation-mediated disorders: from invertebrates to mammals
    Dillin, Andrew
    Cohen, Ehud
    [J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2011, 366 (1561) : 94 - 98
  • [4] Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life
    Fischer, Kathleen E.
    Gelfond, Jonathan A. L.
    Soto, Vanessa Y.
    Han, Chul
    Someya, Shinichi
    Richardson, Arlan
    Austad, Steven N.
    [J]. PLOS ONE, 2015, 10 (05):
  • [5] Late-life rapamycin treatment reverses age-related heart dysfunction
    Flynn, James M.
    O'Leary, Monique N.
    Zambataro, Christopher A.
    Academia, Emmeline C.
    Presley, Michael P.
    Garrett, Brittany J.
    Zykovich, Artem
    Mooney, Sean D.
    Strong, Randy
    Rosen, Clifford J.
    Kapahi, Pankaj
    Nelson, Michael D.
    Kennedy, Brian K.
    Melov, Simon
    [J]. AGING CELL, 2013, 12 (05) : 851 - 862
  • [6] C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation
    Hahm, Jeong-Hoon
    Kim, Sunhee
    DiLoreto, Race
    Shi, Cheng
    Lee, Seung-Jae V.
    Murphy, Coleen T.
    Nam, Hong Gil
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [7] Johnson SC, 2015, INTERD T GERONT GERI, V40, P107, DOI 10.1159/000364974
  • [8] The GH/IGF-1 axis in ageing and longevity
    Junnila, Riia K.
    List, Edward O.
    Berryman, Darlene E.
    Murrey, John W.
    Kopchick, John J.
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2013, 9 (06) : 366 - 376
  • [9] Drugs that modulate aging: the promising yet difficult path ahead
    Kennedy, Brian K.
    Pennypacker, Juniper K.
    [J]. TRANSLATIONAL RESEARCH, 2014, 163 (05) : 456 - 465
  • [10] A C-ELEGANS MUTANT THAT LIVES TWICE AS LONG AS WILD-TYPE
    KENYON, C
    CHANG, J
    GENSCH, E
    RUDNER, A
    TABTIANG, R
    [J]. NATURE, 1993, 366 (6454) : 461 - 464