Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms

被引：9
作者：
das Neves, Sofia P. [1 ,2 ]
Santos, Gisela [3 ]
Barros, Catarina [3 ]
Pereira, Diana Rodrigues [1 ,2 ]
Ferreira, Ricardo [1 ,2 ]
Mota, Cristina [1 ,2 ]
Monteiro, Susana [1 ,2 ]
Fernandes, Adelaide [3 ,4 ]
Marques, Fernanda [1 ,2 ]
Cerqueira, Joao Jose [1 ,2 ,5 ]
机构：
[1] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Campus Gualtar, P-4710057 Braga, Portugal
[2] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal
[3] Univ Lisbon, Fac Pharm, Res Inst Med iMedU Lisboa, Neuron Glia Biol Hlth & Dis, Lisbon, Portugal
[4] Univ Lisbon, Fac Pharm, Dept Biochem & Human Biol, Lisbon, Portugal
[5] Clin Acad Ctr Braga, 2CA, Braga, Portugal
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 340卷
关键词：
Autoimmunity; Multiple sclerosis; Rodent; Experimental autoimmune encephalomyelitis; Dimethyl fumarate; Cognition; FIBRILLARY ACIDIC PROTEIN; MULTIPLE-SCLEROSIS; INFLAMMATION ALTERS; SPATIAL REFERENCE; HIPPOCAMPAL CA1; MESSENGER-RNA; MEMORY; ACTIVATION; ATROPHY; NEUROINFLAMMATION;
D O I：
10.1016/j.jneuroim.2020.577163
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In multiple sclerosis (MS), cognitive dysfunction is common but difficult to treat. We analyzed the impact of dimethyl fumarate, an MS drug with neuroprotective properties, in spatial memory performance in a mouse model of MS and looked for structural correlates in the hippocampus. Treated mice presented better cognitive performance which was not associated with structural hippocampal damage but with decreased demyelination in the fimbria. Dimethyl fumarate, even if initiated after hindlimb paralysis, ameliorated memory deficits in the MS mouse model due, at least in part, to its positive impact in the demyelination of the main hippocampal output pathway.
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页数：11
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