Artificial metallonucleases

被引：415
|
作者：
Mancin, F
Scrimin, P
Tecilla, P
Tonellato, U
机构：
[1] Univ Padua, Dipartimento Sci Chim, I-35131 Padua, Italy
[2] Univ Padua, Ist CNR Tecnol Membrane, Sez Padova, I-35131 Padua, Italy
[3] Univ Trieste, Dipartimento Sci Chim, I-34127 Trieste, Italy
来源：
CHEMICAL COMMUNICATIONS | 2005年 / 20期
关键词：
D O I：
10.1039/b418164f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the realization of synthetic nucleases with particular attention to the strategies that can be pursued to improve efficiency and sequence selectivity.
引用
收藏
页码：2540 / 2548
页数：9
相关论文
共 50 条
  • [21] Theoretical Simulations on Interactions of Mono- and Dinuclear Metallonucleases with DNA
    Liu, Chunmei
    Zhu, Yanyan
    Chen, Peipei
    Tang, Mingsheng
    JOURNAL OF PHYSICAL CHEMISTRY B, 2013, 117 (05): : 1197 - 1209
  • [22] Impact of metallonucleases on DNA interactions: Structural validation and in-vitro antibiogram assay
    Muniyandi, Vellaichamy
    Pravin, Narayanaperumal
    Raman, Natarajan
    INORGANIC CHEMISTRY COMMUNICATIONS, 2014, 46 : 60 - 64
  • [23] Probing of effective pyrazolone based metallonucleases: Molecular docking and in vitro biological critiques
    Arunadevi, Alagarraj
    Paulpandiyan, Rajakkani
    Raman, Natarajan
    APPLIED ORGANOMETALLIC CHEMISTRY, 2018, 32 (10)
  • [24] Molecular Docking Studies on the Metallonucleases and Polyamides with Double-strand DNA Molecules
    Zhu Yan-Yan
    Su Yan-Wei
    Qi Yao
    Tan Hong-Wei
    Wang Yan
    Chen Guang-Ju
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2009, 30 (04): : 781 - 785
  • [25] Cu(II) complexes with hydrazone-functionalized phenanthrolines as self-activating metallonucleases
    Heinrich, Julian
    Stubbe, Jessica
    Kulak, Nora
    INORGANICA CHIMICA ACTA, 2018, 481 : 79 - 86
  • [26] Nucleophile activation in PD ... (D/E)xK metallonucleases: An experimental and computational pKa study
    Xie, Fuqian
    Briggs, James M.
    Dupureur, Cynthia M.
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2010, 104 (06) : 665 - 672
  • [27] Sulfonamide-containing copper(II) metallonucleases: Correlations with in vitro antimycobacterial and antiproliferative activities
    Nakahata, Douglas H.
    de Paiva, Raphael E. F.
    Lustri, Wilton R.
    Ribeiro, Camila M.
    Pavan, Fernando R.
    da Silva, Gisele G.
    Ruiz, Ana L. T. G.
    de Carvalho, Joao E.
    Corbi, Pedro P.
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2018, 187 : 85 - 96
  • [28] Efficient and selective cleavage of RNA Oligonucleotides by calix[4]arene-based synthetic metallonucleases
    Cacciapaglia, Roberta
    Casnati, Alessandro
    Mandolini, Luigi
    Peracchi, Alessio
    Reinhoudt, David N.
    Salvio, Riccardo
    Sartori, Andrea
    Ungaro, Rocco
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (41) : 12512 - 12520
  • [29] Mechanistic Insight into the Catalytic Activity of ββα-Metallonucleases from Computer Simulations: Vibrio vulnificus Periplasmic Nuclease as a Test Case
    Bueren-Calabuig, Juan A.
    Coderch, Claire
    Rico, Eva
    Jimenez-Ruiz, Antonio
    Gago, Federico
    CHEMBIOCHEM, 2011, 12 (17) : 2615 - 2622
  • [30] Copper based metallonucleases as potential antitumor drugs: Synthesis, Structure, in vitro Cytotoxicity and Apoptosis inducing properties
    Zhang, Yong-Po
    Ma, Zhong-Ying
    Qiao, Pei-Pei
    Gao, Chun-Yan
    Tian, Jin-Lei
    Zhao, Jin-Zhong
    Du, Wei-Jun
    Xu, Jing-Yuan
    Yan, Shi-Ping
    JOURNAL OF MOLECULAR STRUCTURE, 2021, 1236
12345